Global Molecular Epidemiology of Respiratory Syncytial Virus from the 2017-2018 INFORM-RSV Study.
Global Molecular Epidemiology of Respiratory Syncytial Virus from the 2017-2018 INFORM-RSV Study.
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DOI：
10.1128/jcm.01828-20
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发表时间：
2020-12-17
影响因子：
9.4
通讯作者：
INFORM-RSV Study Group
中科院分区：
文献类型：
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作者：
Tabor DE;Fernandes F;Langedijk AC;Wilkins D;Lebbink RJ;Tovchigrechko A;Ruzin A;Kragten-Tabatabaie L;Jin H;Esser MT;Bont LJ;Abram ME;INFORM-RSV Study Group
呼吸道合胞病毒（RSV）是婴幼儿下呼吸道感染的主要原因，每年在世界范围内流行。INFORM-RSV是一项为期多年的临床研究，旨在通过监测当前流行RSV毒株的时间和地理演变、F蛋白抗原位点及其与RSV疾病临床特征的关系，描述5岁以下儿童RSV的全球分子流行病学。在试点季节（2017-2018年），从8个国家（英国、西班牙、荷兰、芬兰、日本、巴西、南非和澳大利亚）收集的476份RSV阳性鼻腔样本中获得410个RSV G-F基因序列。呼吸道合胞病毒（RSV）是婴幼儿下呼吸道感染的主要原因，每年在世界范围内流行。INFORM-RSV是一项为期多年的临床研究，旨在通过监测当前流行RSV毒株的时间和地理演变、F蛋白抗原位点及其与RSV疾病临床特征的关系，描述5岁以下儿童RSV的全球分子流行病学。在试点季节（2017-2018年），从8个国家（英国、西班牙、荷兰、芬兰、日本、巴西、南非和澳大利亚）收集的476份RSV阳性鼻腔样本中获得410个RSV G-F基因序列。RSV B（均为BA9基因型）在全球（69.0%对31.0%）和除南非以外的所有国家（均为ON1基因型）中占多数。地理聚类模式强调广泛传播，并随着病毒传播而不断演变。大多数RSV菌株来自1岁以下的婴儿（81.2%）、男性（56.3%）和住院24小时的患者（70.5%），亚型分布无差异。与2013年的参考序列相比，RSV A和B株的F蛋白抗原位点均存在差异，其中RSV B株的抗原位点Ø （I206M/Q209R）和V位点（L172Q/S173L/K191R）存在高频多态性。INFORM-RSV 2017-2018试验季建立了RSV毒株分布和序列变异的重要分子基线，可用于跟踪新毒株的出现，并提供可能影响传播或正在开发的疫苗和单克隆抗体有效性的中和逃逸变异的早期预警系统。
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among infants and young children, resulting in annual epidemics worldwide. INFORM-RSV is a multiyear clinical study designed to describe the global molecular epidemiology of RSV in children under 5 years of age by monitoring temporal and geographical evolution of current circulating RSV strains, F protein antigenic sites, and their relationships with clinical features of RSV disease. During the pilot season (2017–2018), 410 RSV G-F gene sequences were obtained from 476 RSV-positive nasal samples collected from 8 countries (United Kingdom, Spain, The Netherlands, Finland, Japan, Brazil, South Africa, and Australia). Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among infants and young children, resulting in annual epidemics worldwide. INFORM-RSV is a multiyear clinical study designed to describe the global molecular epidemiology of RSV in children under 5 years of age by monitoring temporal and geographical evolution of current circulating RSV strains, F protein antigenic sites, and their relationships with clinical features of RSV disease. During the pilot season (2017–2018), 410 RSV G-F gene sequences were obtained from 476 RSV-positive nasal samples collected from 8 countries (United Kingdom, Spain, The Netherlands, Finland, Japan, Brazil, South Africa, and Australia). RSV B (all BA9 genotype) predominated over RSV A (all ON1 genotype) globally (69.0% versus 31.0%) and in all countries except South Africa. Geographic clustering patterns highlighted wide transmission and continued evolution with viral spread. Most RSV strains were from infants of <1 year of age (81.2%), males (56.3%), and patients hospitalized for >24 h (70.5%), with no differences in subtype distribution. Compared to 2013 reference sequences, variations at F protein antigenic sites were observed for both RSV A and B strains, with high-frequency polymorphisms at antigenic site Ø (I206M/Q209R) and site V (L172Q/S173L/K191R) in RSV B strains. The INFORM-RSV 2017–2018 pilot season establishes an important molecular baseline of RSV strain distribution and sequence variability with which to track the emergence of new strains and provide an early warning system of neutralization escape variants that may impact transmission or the effectiveness of vaccines and MAbs under development.