2-Fluoro-1,3-benzodithiole-1,1,3,3-tetraoxide: a reagent for nucleophilic monofluoromethylation of aldehydes.
2-Fluoro-1,3-benzodithiole-1,1,3,3-tetraoxide: a reagent for nucleophilic monofluoromethylation of aldehydes.
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DOI：
10.1002/anie.200906866
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发表时间：
2010-02
影响因子：
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通讯作者：
T. Furukawa;Y. Goto;Jumpei Kawazoe;Etsuko Tokunaga;Shuichi Nakamura;Yudong Yang;H. Du;A. Kakehi,-A.-Kakeh
中科院分区：
文献类型：
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作者：
T. Furukawa;Y. Goto;Jumpei Kawazoe;Etsuko Tokunaga;Shuichi Nakamura;Yudong Yang;H. Du;A. Kakehi,-A.-Kakeh
选择题：标题化合物（FBDT）是1-氟双（苯磺酰基）甲烷（FBSM）的环状类似物，被开发为醛的亲核单氟甲基化试剂。通过选择合适的碱，可以实现FBDT与共轭醛的选择性1，2-或1，4-加成。该方法被应用于合成一种含氟的紫丁香内酯电子等排体。
" Chemical Equation Presented" Matter of choice: The title compound (FBDT), a cyclic analogue of 1-fluorobis (phenylsulfonyl) methane (FBSM), was developed as a reagent for the nucleophilic monofluoromethylation of aldehydes. By choice of an appropriate base it is possible to achieve selective 1, 2-or 1, 4addition of FBDT to conjugated aldehydes. The method was applied to the synthesis of a fluorinated isostere of osmundalactone.