Effects of β-(1,3-1,6)-D-glucan on irritable bowel syndrome-related colonic hypersensitivity
Effects of β-(1,3-1,6)-D-glucan on irritable bowel syndrome-related colonic hypersensitivity
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DOI：
10.1016/j.bbrc.2012.03.015
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发表时间：
2012-04-06
影响因子：
3.1
通讯作者：
Mizushima, Tohru
中科院分区：
文献类型：
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作者：
Asano, Teita;Tanaka, Ken-ichiro;Mizushima, Tohru
肠易激综合征(IBS)是一种以慢性腹痛为特征的胃肠道疾病，与排便习惯改变有关。由于IBS的患病率非常高，因此涉及到更高的医疗费用，因此用非处方药的方法治疗这种情况可能是有益的。含有1.6个支链的β-(1，3)-D-葡聚糖(β-葡聚糖)多年来一直被用作营养补充剂。在这项研究中，我们研究了β-葡聚糖对IBS动物模型粪便小球产量和内脏疼痛反应的影响。口服β-葡聚糖可抑制束缚应激或药物诱导的粪便小球排泄量。β-葡聚糖也抑制了结直肠扩张引起的内脏疼痛反应。这些结果表明，β-葡聚糖对IBS的治疗和预防可能是有益的。(C)2012年，爱思唯尔公司出版。
Irritable bowel syndrome (IBS) is a gastrointestinal disorder characterized by chronic abdominal pain associated with altered bowel habits. Since the prevalence of IBS is very high and thus, involves elevated health-care costs, treatment of this condition by methods other than prescribed medicines could be beneficial. beta-(1,3)-D-glucan with beta-(1.6) branches (beta-glucan) has been used as a nutritional supplement for many years. In this study, we examined the effect of beta-glucan on fecal pellet output and visceral pain response in animal models of IBS. Oral administration of beta-glucan suppressed the restraint stress- or drug-induced fecal pellet output. beta-Glucan also suppressed the visceral pain response to colorectal distension. These results suggest that beta-glucan could be beneficial for the treatment and prevention of IBS. (C) 2012 Published by Elsevier Inc.