Melanopsin: An opsin in melanophores, brain, and eye
Melanopsin: An opsin in melanophores, brain, and eye
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DOI：
10.1073/pnas.95.1.340
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发表时间：
1998-01-06
影响因子：
11.1
通讯作者：
Rollag, MD
中科院分区：
文献类型：
--
作者：
Provencio, I;Jiang, GS;Rollag, MD
我们已经确定了视蛋白，黑视蛋白，在感光皮肤黑色素细胞的非洲爪蟾。其推导的氨基酸序列与头足类视蛋白具有最大的同源性，黑视蛋白的预测二级结构表明存在具有多个推定磷酸化位点的长胞质尾，这表明该视蛋白的功能可能受到精细调节。黑视蛋白mRNA在下丘脑部位（被认为包含脑深部光感受器）和虹膜中表达，虹膜是已知在两栖动物中直接感光的结构。黑视素信使还定位于位于内核层的最外层的视网膜细胞中，在该最外层中通常发现水平细胞。其在视网膜和非视网膜组织中的表达表明在视觉和非视觉光感受任务中的作用，例如皮肤色素沉着的光控制、瞳孔孔径以及昼夜节律和光周期生理学。
We have identified an opsin, melanopsin, in photosensitive dermal melanophores of Xenopus laevis. Its deduced amino acid sequence shares greatest homology with cephalopod opsins, The predicted secondary structure of melanopsin indicates the presence of a long cytoplasmic tail with multiple putative phosphorylation sites, suggesting that this opsin's function may be finely regulated, Melanopsin mRNA is expressed in hypothalamic sites thought to contain deep brain photoreceptors and in the iris, a structure known to be directly photosensitive in amphibians. Melanopsin message is also localized in retinal cells residing in the outermost lamina of the inner nuclear layer where horizontal cells are typically found, Its expression in retinal and nonretinal tissues suggests a role in vision and nonvisual photoreceptive tasks, such as photic control of skin pigmentation, pupillary aperture, and circadian and photoperiodic physiology.