Predicting the severity of systemic inflammatory response syndrome (SIRS)-associated coagulopathy with hemostatic molecular markers and vascular endothelial injury markers
Predicting the severity of systemic inflammatory response syndrome (SIRS)-associated coagulopathy with hemostatic molecular markers and vascular endothelial injury markers
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DOI：
10.1097/01.ta.0000251420.41427.d3
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发表时间：
2007-11-01
影响因子：
--
通讯作者：
Shimazaki, Shuji
中科院分区：
文献类型：
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作者：
Iba, Toshiaki;Gando, Satoshi;Shimazaki, Shuji
简介：全身炎症反应综合征（SIRS）患者凝血或纤溶、抗凝、炎症和内皮损伤等生物标志物发生变化。本研究的目的是评估这些标志物在SIRS相关高凝血症患者中的预后价值。方法：在三所大学医院的重症监护病房中，66名血小板计数低于15.0 × 10（4）/mm（3）的SIRS患者被纳入本前瞻性比较研究。在第0天和第2天采集血样。测量了12项止血、炎症和血管内皮指标，并比较了重度组（最大序贯器官衰竭评估评分为10分或以上的患者和死亡者; n = 25）和轻度组（序贯器官衰竭评估评分为10分或以上的患者）之间的数据
Introduction: The changes in biomarkers of coagulation or fibrinolysis, anticoagulation, inflammation, and endothelial damage occur in patients with systemic inflammatory response syndrome (SIRS). The purpose of this study is to assess the prognostic value of these markers in patients with SIRS-associated hypercoagulopathy.Methods: Sixty-six SIRS patients with a platelet count less than 15.0 x 10(4)/mm(3) in three university hospital intensive care units were enrolled in this prospective, comparative study. Blood samples were obtained on day 0 and day 2. Twelve hemostatic, inflammatory, and vascular endothelial indices were measured and the data were compared between the severe group (patients with a total maximum Sequential Organ Failure Assessment score of 10 or more and nonsurvivors; n = 25) and the lesssevere group (Sequential Organ Failure Assessment score