Targeting sphingolipid metabolism in head and neck cancer: rational therapeutic potentials.
Targeting sphingolipid metabolism in head and neck cancer: rational therapeutic potentials.
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DOI：
10.1517/14728221003752768
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发表时间：
2010-05
影响因子：
5.8
通讯作者：
Liu X
中科院分区：
文献类型：
--
作者：
Beckham TH;Elojeimy S;Cheng JC;Turner LS;Hoffman SR;Norris JS;Liu X
神经酰胺积累已被证明是正常生理过程中以及对癌症治疗如放疗和化疗的响应中细胞凋亡起始的保守机制。因此，毫不奇怪，许多癌症发生鞘脂代谢异常，其阻止神经酰胺的积累，无论是通过减少神经酰胺产生还是通过增强神经酰胺催化剂，当催化剂导致产生促肿瘤鞘氨醇-1-磷酸和神经酰胺-1-磷酸时特别危险。许多研究表明，头颈部肿瘤中的鞘脂代谢失调。鞘脂类和鞘脂类代谢在癌症中的作用进行了审查，读者将带来最新的发现，在该领域的鞘脂类代谢在头部和颈部癌症。这篇综述旨在强调鞘脂代谢的重要性，并将鞘脂代谢带到头颈癌新疗法研究的前沿。此外，它将审查鞘脂为中心的治疗正在调查中的临床前和临床试验的头部和颈部癌症。由于目前头颈部癌症的治疗方法有限，在我们寻求新的方法来对抗这种危险的肿瘤时，应该考虑靶向鞘脂代谢的潜力。
Ceramide accumulation has been shown to be a conserved mechanism of apoptosis initiation in normal physiological processes as well as in response to cancer treatments such as radiation and chemotherapy. Therefore, it is unsurprising that many cancers develop aberrations of sphingolipid metabolism that prevent the accumulation of ceramide, whether by reduction of ceramide generation or by enhanced ceramide catabolism, particularly dangerous when catabolism leads to generation of pro-tumor sphingosine-1-phosphate and ceramide-1-phosphate. Numerous studies have now implicated dysregulation of sphingolipid metabolism in head and neck cancers. The roles of sphingolipids and sphingolipid metabolism in cancer are reviewed and the reader will be brought up to date with discoveries in the field of sphingolipid metabolism in head and neck cancer. This review seeks to highlight the importance of sphingolipid metabolism and to bring sphingolipid metabolism to the forefront in the investigation of novel therapies for head and neck cancer. Further, it will review sphingolipid-centric therapies under investigation in preclinical and clinical trials of cancers of the head and neck. As treatments for head and neck cancers are currently limited, the potentials of targeting sphingolipid metabolism should be taken into consideration as we seek novel ways to combat this dangerous group of tumors.
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