Heidelberg Ion Therapy Center (HIT): Initial clinical experience in the first 80 patients
Heidelberg Ion Therapy Center (HIT): Initial clinical experience in the first 80 patients
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DOI：
10.3109/0284186x.2010.498432
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发表时间：
2010-10-01
期刊：
影响因子：
3.1
通讯作者：
Debus, Juergen
中科院分区：
文献类型：
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作者：
Combs, Stephanie E.;Ellerbrock, Malte;Debus, Juergen
海德堡离子治疗中心 (HIT) 于 2009 年 11 月开始临床运营。在本报告中，我们介绍了首批 80 名接受质子和碳离子放射治疗的患者，并描述了针对不同适应症的患者选择、治疗计划和日常治疗。患者和方法。 2009年11月15日至2010年4月15日期间，80名患者在海德堡离子治疗中心（HIT）接受了碳离子和质子放射治疗。主要治疗适应症包括颅底脊索瘤（n=9）和软骨肉瘤（n=18）、恶性唾液腺肿瘤（n=29）、骶骨脊索瘤（n=5）、低度恶性胶质瘤（n=3）、原发性和复发性恶性星形细胞瘤和胶质母细胞瘤（n=7）以及骨肉瘤（n=3）。在这些患者中，有 4 名 18 岁以下的儿科患者接受了治疗。结果。所有患者均使用调强光栅扫描技术进行治疗。 76 名患者接受碳离子治疗（95%），4 名患者接受质子治疗。所有患者在每次分次之前均进行 X 射线成像。治疗概念基于 Gesellschaft Fur Schwerionenforschung (GSI) 的碳离子治疗的初步经验，包括纯碳治疗和光子调强放射治疗碳增强治疗。每位患者每次分次在治疗室的平均时间为 29 分钟；仅就照射而言，包括所有患者在内的平均时间为 16 分钟。在每个治疗部分之前使用正交 X 射线成像进行位置验证。结论。粒子治疗可以成功地纳入海德堡放射肿瘤科的临床常规。随后将启动大量临床试验，以精确定义质子和碳离子放射治疗在放射肿瘤学中的作用。
The Heidelberg Ion Therapy Center (HIT) started clinical operation in November 2009. In this report we present the first 80 patients treated with proton and carbon ion radiotherapy and describe patient selection, treatment planning and daily treatment for different indications. Patients and methods. Between November 15, 2009 and April 15, 2010, 80 patients were treated at the Heidelberg Ion Therapy Center (HIT) with carbon ion and proton radiotherapy. Main treated indications consisted of skull base chordoma (n=9) and chondrosarcoma (n=18), malignant salivary gland tumors (n=29), chordomas of the sacrum (n=5), low grade glioma (n=3), primary and recurrent malignant astrocytoma and glioblastoma (n=7) and well as osteosarcoma (n=3). Of these patients, four pediatric patients aged under 18 years were treated. Results. All patients were treated using the intensity-modulated rasterscanning technique. Seventy six patients were treated with carbon ions (95%), and four patients were treated with protons. In all patients x-ray imaging was performed prior to each fraction. Treatment concepts were based on the initial experiences with carbon ion therapy at the Gesellschaft fur Schwerionenforschung (GSI) including carbon-only treatments and carbon-boost treatments with photon-IMRT. The average time per fraction in the treatment room per patient was 29 minutes; for irradiation only, the mean time including all patients was 16 minutes. Position verification was performed prior to every treatment fraction with orthogonal x-ray imaging. Conclusion. Particle therapy could be included successfully into the clinical routine at the Department of Radiation Oncology in Heidelberg. Numerous clinical trials will subsequently be initiated to precisely define the role of proton and carbon ion radiotherapy in radiation oncology.