Diurnal Changes in Serum Metabolites and Hormones in Lean and Obese Zucker Rats*
Diurnal Changes in Serum Metabolites and Hormones in Lean and Obese Zucker Rats*
复制标题
瘦和肥胖 Zucker 大鼠血清代谢物和激素的昼夜变化*
DOI：
10.1055/s-0028-1093431
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发表时间：
1978
影响因子：
2.2
通讯作者：
J. Gahagan
中科院分区：
文献类型：
--
作者：
R. Martin;P. J. Wangsness;J. Gahagan
研究了遗传上瘦和肥胖的Zucker大鼠的血清激素水平的日模式。24小时内，肥胖者血糖和胰岛素升高；免疫反应性胰岛素是肥胖大鼠的12倍。瘦鼠和肥胖鼠血清中三碘甲状腺原氨酸、促甲状腺激素和催乳素的水平也有类似的变化模式。在峰值水平上，瘦大鼠催乳素是肥胖大鼠的2.5倍（P < 0.01）。在整个采样期间，肥胖大鼠的甲状腺素水平往往低于瘦大鼠。肥胖大鼠的生长激素水平严重下降，在周期较轻的时期，瘦鼠和肥胖大鼠之间的差异最大。这些生长激素分泌的差异可能是肥胖大鼠氮潴留受损的原因。血清皮质酮水平在黑暗周期开始时最高，随后在瘦鼠中急剧下降。肥胖大鼠没有表现出明显的皮质酮分泌模式，并且在整个测试期间趋于升高。
A study of diurnal patterns of serum hormone levels was made in genetically lean and obese Zucker rats. Serum glucose and insulin were elevated in the obese through the 24-hour period; immunoreactive insulin being 12 times higher in the obese rat. A similar pattern of serum hormone levels in lean and obese rats was found for triiodothyronine, thyroid stimulating hormone and prolactin. At peak levels, prolactin was 2.5 times higher in lean than obese rats (P is less than .01). Thyroxine levels tended to be lower in the obese rats throughout the sampling periods when compared to lean rats. Growth hormone levels were severely depressed in the obese rat with the largest differences between lean and obese rats being observed during the light periods of the cycle. These differences in growth hormone secretion may be responsible for the impaired nitrogen retention in the obese rat. Serum levels of corticosterone were highest at the beginning of the dark cycle and decreased drastically thereafter in the lean rats. The obese rat did not exhibit a distinct pattern of corticosterone secretion and tended to be elevated throughout the periods tested.