Cardiac production of C-type natriuretic peptide in heart failure
Cardiac production of C-type natriuretic peptide in heart failure
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DOI：
10.2459/01.jcm.0000228688.94709.5a
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发表时间：
2006-06-01
影响因子：
3
通讯作者：
Giannessi, Daniela
中科院分区：
文献类型：
--
作者：
Del Ry, Silvia;Maltinti, Maristella;Giannessi, Daniela
背景 最近，通过测量主动脉根部和冠状窦样本之间 C 型利钠肽血浆水平的差异，证明了慢性心力衰竭患者心脏产生的 C 型利钠肽。为了评估之前的相关观察结果，我们重新评估了 C 型利尿钠肽的心脏产生，从而增加了研究的患者总数。鉴于招募具有这些特征的患者存在困难，此类研究可以在少数受试者中进行。 方法对转至我院慢性心力衰竭评估中心的一组患者（n = 6）评估心脏产生的C型利钠肽。固相提取血浆样本后，使用特异性免疫测定法测量右心导管插入术期间收集的冠状窦和主动脉血液中的 C 型利钠肽。结果发现，冠状窦中的 C 型利钠肽水平显着高于主动脉血液（7.8 +/- 1.3 与 6.1 +/- 1.5 pg/ml，P = 0.034），我们的结果与之前的结果一致。总体分析这两项研究中收集的数据，观察到两个部位的 C 型利钠肽浓度显着增加（n = 15，P = 0.002）。 结论 本研究的结果强化了慢性心力衰竭患者的 C 型利钠肽由心脏产生的假设。 J Cardiovasc Med 7：397-399 (C) 2006 意大利心脏病学联合会。
Background C-type natriuretic peptide production by the heart in patients with chronic heart failure has recently been demonstrated by measuring the difference in C-type natriuretic peptide plasma levels between the aortic root and coronary sinus samples. To assess this previous relevant observation, we re-evaluated the cardiac production of C-type natriuretic peptide, thus increasing the total number of patients studied. In light of the difficulty in recruiting patients with these characteristics, this kind of study can be performed with a small number of subjects.Methods Cardiac production of C-type natriuretic peptide was evaluated in a subset (n = 6) of patients, referred to our institute for the evaluation of chronic heart failure. C-type natriuretic peptide was measured in the coronary sinus and in aorta blood collected during right and left heart catheterization using a specific immunometric assay, after solid-phase extraction of plasma samples.Results Significantly higher C-type natriuretic peptide levels were found in the coronary sinus than in aorta blood (7.8 +/- 1.3 versus 6.1 +/- 1.5 pg/ml, P = 0.034) and our results were in accordance with previous ones. Analysing as a whole the data gathered in the two studies, a noteworthy significant increase was observed (n = 15, P = 0.002) between the C-type natriuretic peptide concentrations in the two sites.Conclusions The results of the present study strengthen the hypothesis that C-type natriuretic peptide is produced by the heart in patients with chronic heart failure. J Cardiovasc Med 7: 397-399 (C) 2006 Italian Federation of Cardiology.