Dual H-bond activation of NHC-Au(I)-Cl complexes with amide functionalized side-arms assisted by H-bond donor substrates or acid additives.
Dual H-bond activation of NHC-Au(I)-Cl complexes with amide functionalized side-arms assisted by H-bond donor substrates or acid additives.
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DOI：
10.1039/d0cc05999d
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发表时间：
2020-11
影响因子：
4.9
通讯作者：
Otto Seppänen;Santeri Aikonen;Mikko Muuronen;Carla Alamillo-Ferrer;J. Burés;J. Helaja
中科院分区：
文献类型：
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作者：
Otto Seppänen;Santeri Aikonen;Mikko Muuronen;Carla Alamillo-Ferrer;J. Burés;J. Helaja
用酰胺系留氢键供体的NHC配体通过氢键实现Au(I)催化的新方法。普通的NHC-Au(I)-Cl络合物在DCM中催化末端N-丙酰胺转化为恶唑啉，并在酸性添加剂的作用下催化烯炔环异构化。密度泛函理论计算揭示了侧臂在激活过程中的作用。
Novel approach with amide-tethered H-bond donor NHC ligands enabled Au(i)-catalysis via H-bonding. The plain NHC-Au(i)-Cl complex catalysed conversions of terminal N-propynamides to oxazolines, and enyne cycloisomerization with an acid additive, in DCM at RT. DFT calculations enlightened the function of the side-arm in the activation.