THE MYOFIBROBLAST ANCHORING STRAND - THE FIBRONECTIN CONNECTION IN WOUND-HEALING AND THE POSSIBLE LOCI OF COLLAGEN FIBRIL ASSEMBLY
THE MYOFIBROBLAST ANCHORING STRAND - THE FIBRONECTIN CONNECTION IN WOUND-HEALING AND THE POSSIBLE LOCI OF COLLAGEN FIBRIL ASSEMBLY
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DOI：
10.1097/00005373-198310000-00001
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发表时间：
1983-01-01
影响因子：
--
通讯作者：
PARKS, DH
中科院分区：
文献类型：
--
作者：
BAUR, PS;PARKS, DH
肌成纤维细胞锚定链（MAS）是将肌成纤维细胞内的肌动蛋白束的末端连接到伤口愈合组织的细胞外间隙中的胶原纤维束的细胞外结构。链似乎主要由直径为2-5 nm的纤连蛋白微纤维组成。它们还包含中间尺寸细丝（ISF）的平行阵列和胶原的无定形基质。MAS有效地将细胞运动所需的细胞收缩力转化为伤口收缩所需的胶原丝/纤维变形。然而，链的主要功能似乎是将ISF组装成胶原纤维。
Myofibroblast anchoring strands (MAS) are extracellular structures that connect the termini of actin bundles within myofibroblasts to collagen fascicles in the extracellular space of wound healing tissues. The strands appear to be primarily comprised of microfibrils of fibronectin 2–5 nm in diameter. They also embody parallel arrays of intermediary sized filaments (ISF) and an amorphous matrix of collagen. The MAS effectively translate the cellular contractile forces required for cell motility into the collagen filament/fiber deformations required for wound contraction. However, the primary function of the strands appears to be the assembly of ISF into collagen fibrils.