Hippocampal pathologic findings in schizophrenia. A morphometric study.
Hippocampal pathologic findings in schizophrenia. A morphometric study.
复制标题
精神分裂症的海马病理结果。
作者：
D. Jeste;J. Lohr
我们研究了来自雅科夫列夫大脑收藏的 13 名精神分裂症患者、9 名非精神分裂症患者和 16 名正常对照的海马切片。三组的年龄、性别分布和脑重量相似。大多数患者从未接受过抗精神病药，并且两个患者组接受了相似类型的白细胞切除术。我们使用半自动图像分析系统来计算左右海马角的四个部分（Ca1 至 CA4）中每个部分的体积和锥体细胞密度。精神分裂症患者的切片在所有部分中几乎始终具有最低的体积和锥体细胞密度。左侧 CA4 的差异最大，精神分裂症患者的锥体细胞密度显着低于正常对照，体积显着低于白细胞切除术对照。我们的研究结果证实了最近几项显示精神分裂症海马病理特征的研究结果。然而，我们的研究表明，精神分裂症的海马神经病理学发现可能比以前报道的更微妙、更局部。
We studied hippocampal sections from 13 schizophrenic patients, 9 nonschizophrenic patients, and 16 normal controls from the Yakovlev brain collection. The three groups were similar in age, gender distribution, and brain weight. Most patients had never received neuroleptics, and the two patient groups had had similar types of leukotomies. We used a semiautomated image analysis system to compute volume and pyramidal-cell density in each of the four sectors of the cornu ammonis, Ca1 through CA4, in the right and left hippocampi. Sections from schizophrenic patients had almost consistently the lowest volume and pyramidal-cell density in all sectors. The differences were greatest in left CA4, with schizophrenic patients having significantly lower pyramidal-cell density than normal controls and significantly lower volume than leukotomy controls. Our findings confirm the results of several recent studies showing hippocampal pathologic features in schizophrenia. Our study suggests, however, that the hippocampal neuropathologic findings in schizophrenia may be more subtle and more localized than those reported previously.
精神分裂症中海马锥体细胞的方向。
影响因子：
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作者：
Altshuler,LL;Conrad,A;Kovelman,JA;Scheibel,A
通讯作者：
Scheibel,A
影响因子：
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作者：
MEDNICK, SA;MACHON, RA;BONETT, D
通讯作者：
BONETT, D