The relationship between physical activity and lipoprotein subclasses in postmenopausal women: the influence of hormone therapy.
The relationship between physical activity and lipoprotein subclasses in postmenopausal women: the influence of hormone therapy.
复制标题
绝经后妇女体力活动与脂蛋白亚类之间的关系：激素治疗的影响。
DOI：
10.1097/01.gme.0000229573.29258.d5
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Kuller,LewisH
中科院分区：
文献类型：
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作者：
Pettee,KelleyK;Kriska,AndreaM;Johnson,BDelia;Conroy,MollyB;Mackey,RachelH;Orchard,TrevorJ;Kuller,LewisH
目的：本研究的目的是确定绝经后妇女的体力活动与血脂和脂蛋白亚类之间的关系是否因激素治疗(HT)的使用而不同。设计：在485名绝经后(平均年龄56.9[2.9]岁)白人和非洲裔美国妇女参加活动和营养研究之前，研究了体力活动与脂类和脂蛋白亚类关系的横断面关系。这项研究是一项随机临床试验，旨在测试生活方式干预是否会减少亚临床心血管疾病的测量。结果：与不使用激素的人(n=196)相比，使用激素治疗的人(n=286)显著年轻(P<；0.05)，不太可能是非裔美国人，报告的体力活动水平更高，大的极低密度脂蛋白(VLDL-P)和中等高密度脂蛋白(HDLP)的平均大小更大，总胆固醇、低密度脂蛋白(LDL)胆固醇、小HDLP和小VLDL-P的水平更低。体力活动与有利的脂蛋白和脂类水平显著相关，与使用羟色胺无关。一些关系被发现因使用羟色胺而显著不同。在非使用者中，随着活动的增加，高密度脂蛋白和低密度脂蛋白颗粒(LDL-P)的平均尺寸显著增大(P=0.01和0.05)，总的和少量的低密度脂蛋白显著降低(均P=0.02)。结论：运动与某些脂蛋白亚类显著相关，但几个关键的脂蛋白亚类仅在非羟色胺使用者中与较高的活动水平相关。
Objective:This study's objective was to determine if the association between physical activity and lipids and lipoprotein subclasses in postmenopausal women varies by hormone therapy (HT) use.Design:The cross-sectional relationship between physical activity and lipid and lipoprotein subclass relationship was examined before group randomization in 485 postmenopausal (mean age 56.9 [2.9] y) white and African American women from the Woman On the Move through Activity and Nutrition study. This study is a randomized clinical trial designed to test whether a lifestyle intervention will reduce subclinical cardiovascular disease measures.Results:Hormone therapy users (n= 286) were significantly (P< 0.05) younger, less likely to be African American, reported higher levels of physical activity, large very low-density lipoprotein particles (VLDL-P), and medium high-density lipoprotein particles (HDL-P), had a larger mean HDL-P size, and lower levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, small HDL-P, and small VLDL-P than nonusers (n= 196). Physical activity was significantly associated with favorable lipoprotein and lipid levels, regardless of HT use. Some relationships were found to vary significantly by HT use. In nonusers, mean HDL-P and LDL particles (LDL-P) size was significantly larger (P= 0.01 and 0.05, respectively) and total and small LDL-P were significantly lower (both P= 0.02) as activity increased. These relationship were not found in HT users.Conclusions:Physical activity was significantly related to some lipoprotein subclasses regardless of HT; however, several key lipoprotein subclasses were associated with higher levels of activity only among non-HT users.