Analgesic dorsal root ganglionic field stimulation blocks conduction of afferent impulse trains selectively in nociceptive sensory afferents.
Analgesic dorsal root ganglionic field stimulation blocks conduction of afferent impulse trains selectively in nociceptive sensory afferents.
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DOI：
10.1097/j.pain.0000000000001982
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发表时间：
2020-12
期刊：
影响因子：
7.4
通讯作者：
Pan B
中科院分区：
文献类型：
--
作者：
Chao D;Zhang Z;Mecca CM;Hogan QH;Pan B
周围神经损伤后初级感觉神经元兴奋性增加可引起痛觉过敏和异常性疼痛。背根神经节场刺激（GFS）可有效缓解动物模型中与神经损伤和神经病理性疼痛相关的临床疼痛。但是，其机制尚未确定。我们研究了GFS对从外周到中枢过程的动作电位（AP）的传输的影响，通过在体单单位记录从假损伤大鼠和胫神经损伤（TNI）大鼠的腰后根在纤维类型定义的传导速度。在C型单位中，由GFS（20 Hz）直接产生的AP的传输在20 s内逐渐减弱，而GFS诱导的Aβ活性持续不减弱，而Aδ显示中间模式。在C型单位中，通过坐骨神经的电刺激和感受野（无毛皮肤）的点状机械刺激产生的外周活动同样在20 s内被GFS完全阻断，而Aβ单位受到的影响最小，Aδ单位的亚群被阻断。胫神经损伤后，点状机械刺激诱发AP放电的阈值（von Frey）降低，在GFS期间恢复正常。这些结果还表明，C型纤维，而不是Aβ，主要有助于损伤后的机械和热过敏（von Frey，bush，丙酮）。GFS产生传入AP串的使用依赖性阻断，这与感觉神经元T接头处AP的增强过滤一致，特别是在伤害性单位中。电刺激背根神经节通过选择性阻断来自躯体和外周末梢的伤害性感觉传入而提供有效的镇痛
Increased excitability of primary sensory neurons after peripheral nerve injury may cause hyperalgesia and allodynia. Dorsal root ganglion field stimulation (GFS) is effective in relieving clinical pain associated with nerve injury and neuropathic pain in animal models. However, its mechanism has not been determined. We examined effects of GFS on transmission of action potentials (APs) from the peripheral to central processes by in vivo single unit recording from lumbar dorsal roots in sham injured rats and rats with tibial nerve injury (TNI) in fiber types defined by conduction velocity. Transmission of APs directly generated by GFS (20Hz) in C-type units progressively abated over 20s, whereas GFS-induced Aβ activity persisted unabated, while Aδ showed an intermediate pattern. Activity generated peripherally by electrical stimulation of the sciatic nerve and punctate mechanical stimulation of the receptive field (glabrous skin) was likewise fully blocked by GFS within 20s in C-type units, whereas Aβ units were minimally affected and a subpopulation of Aδ units were blocked. After tibial nerve injury, the threshold to induce AP firing by punctate mechanical stimulation (von Frey) was reduced, which was reversed to normal during GFS. These results also suggest that C-type fibers, not Aβ, mainly contribute to mechanical and thermal hypersensitivity (von Frey, bush, acetone) after injury. GFS produces use-dependent blocking of afferent AP trains, consistent with enhanced filtering of APs at the sensory neuron T-junction, particularly in nociceptive units. Electrical stimulation of the dorsal root ganglion provides effective analgesia by selectively blocking nociceptive sensory afferents from somata and peripheral endings
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DOI：
10.1172/jci86812
发表时间：
2017-05-01
期刊：
The Journal of clinical investigation
影响因子：
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作者：
Du X;Hao H;Yang Y;Huang S;Wang C;Gigout S;Ramli R;Li X;Jaworska E;Edwards I;Deuchars J;Yanagawa Y;Qi J;Guan B;Jaffe DB;Zhang H;Gamper N
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10.1523/jneurosci.5053-10.2011
发表时间：
2011-03-09
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
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作者：
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通讯作者：
Hogan QH
伤害感受神经元体膜电位的控制及其对外周伤害感受传递的影响。
影响因子：
7.4
作者：
Du X;Hao H;Gigout S;Huang D;Yang Y;Li L;Wang C;Sundt D;Jaffe DB;Zhang H;Gamper N
通讯作者：
Gamper N
影响因子：
2.8
作者：
Koopmeiners, Andrew S.;Mueller, Samantha;Hogan, Quinn H.
通讯作者：
Hogan, Quinn H.
影响因子：
5.5
作者：
Fang, X;McMullan, S;Djouhri, L
通讯作者：
Djouhri, L