Chemical Composition and Anticholinesterase Activity of the Essential Oil from the Ecuadorian Plant Salvia pichinchensis Benth
Chemical Composition and Anticholinesterase Activity of the Essential Oil from the Ecuadorian Plant Salvia pichinchensis Benth
复制标题
厄瓜多尔植物鼠尾草精油的化学成分和抗胆碱酯酶活性
DOI：
10.25135/rnp.164.19.07.1342
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发表时间：
2020
影响因子：
1.9
通讯作者：
Chabaco Armijos
中科院分区：
文献类型：
--
作者：
M. Salinas;N. Bec;J. Calva;Jorge Ramírez;J. M. Andrade;C. Larroque;G. Vidari;Chabaco Armijos
皮钦丹参（Salvia pichinchensis Benth）采集于厄瓜多尔南部，其精油（EO）从地上部分蒸馏提取，并通过气相色谱 - 质谱联用仪（GC - MS）和气相色谱 - 氢火焰离子化检测器（GC - FID）进行分析。测定了其物理性质、化学成分以及胆碱酯酶抑制活性。鉴定出六种主要成分，均为倍半萜烯：顺式-1(6),4-荜澄茄二烯（17.11%）（1）、γ-姜黄烯（13.75%）（2）、（E）-石竹烯（12.58%）（3）、（E,E）-α-法尼烯（10.00%）（4）、α-古芸烯（9.46%）（5）和别香树烯（6.96%）（6）。该精油对丁酰胆碱酯酶显示出有趣的选择性抑制活性（50.70μg/mL），而对乙酰胆碱酯酶仅具有较低的抑制活性（117.60μg/mL）。皮钦丹参精油的化学成分和丁酰胆碱酯酶活性首次被报道。
Salvia pichinchensis Benth was collected in the South of Ecuador and the essential oil (EO) was distilled from aerial parts and analyzed by GC-MS and GC-FID. The physical properties, chemical composition, and cholinesterase inhibitory activity were determined. Six major components, all sesquiterpenes, were identified: cis-cadina-1(6),4-diene (17.11%) (1), γ-curcumene (13.75%) (2), (E)-caryophyllene (12.58%) (3), (E,E)-α-farnesene (10.00%) (4), α-gurjunene (9.46%) (5) and allo-aromadendrene (6.96%) (6). The EO showed an interesting selective inhibitory activity against the enzyme butyrylcholinesterase (50.70 μg/mL) and only low inhibitory activity against acetylcholinesterase (117.60 μg/mL). The chemical composition and butyrylcholinesterase activity of the EO of S. pichinchensis Benth was reported for first time.