Photofragmentation of phototoxic dibenzocycloheptadiene antidepressants.
Photofragmentation of phototoxic dibenzocycloheptadiene antidepressants.
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光毒性二苯并环庚二烯抗抑郁药的光裂解。
DOI：
10.1111/j.1751-1097.1988.tb08836.x
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发表时间：
1988
影响因子：
3.3
通讯作者：
Kumar,A
中科院分区：
文献类型：
--
作者：
Epling,GA;Sibley,MT;Chou,TT;Kumar,A
本文测定了一类光毒性三环类抗抑郁药在有氧和无氧条件下的光化学反应产物。在所有条件下，光毒性化合物的光致碎片化都是一个重要的反应-在某些情况下，它几乎是观察到的唯一光反应。光反应的机理似乎涉及从侧链的激发态电子转移，得到反应性激基复合物，其通过自由基和离子途径断裂。这些活性中间体可能有助于这些化合物的体内光毒性。
The products of photochemical reaction of a family of phototoxic tricyclic antidepressants have been determined, both in the presence and absence of oxygen. Under all conditions photofrag‐mentation of the phototoxic compounds is an important reaction‐in some cases it is virtually the only photoreaction observed. The mechanism of photoreaction appears to involve excited state electron transfer from the side chain to give a reactive exciplex, which fragmentsviaboth radical and ionic pathways. These reactive intermediates are likely to contribute to thein vivophototoxicity of these compounds.