Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2
Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2
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DOI：
10.1016/s0896-6273(01)00407-x
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发表时间：
2001-09-13
期刊：
影响因子：
16.2
通讯作者：
Jessell, TM
中科院分区：
文献类型：
--
作者：
Novitch, BG;Chen, AI;Jessell, TM
在发育中的脊椎动物神经系统中，协调神经元亚型身份与神经元分化的一般特征的机制尚不清楚。我们在这里表明bHLH蛋白Olig2在运动神经元祖细胞中选择性表达，并在确定发育中的运动神经元的亚型身份和泛神经元特性方面发挥关键作用。Olig2在运动神经元亚型身份规范中的作用取决于与祖同源结构域蛋白的调节相互作用，而其在促进泛神经元特性方面的作用与另一种bHLH蛋白Ngn2的表达有关。Olig2功能的两个方面似乎都依赖于其作为转录抑制因子的活性。综上所述，这些研究表明，Olig2在整合发育中的脊髓运动神经元分化的各种特征方面起着关键作用。
Within the developing vertebrate nervous system, the mechanisms that coordinate neuronal subtype identity with generic features of neuronal differentiation are poorly defined. We show here that a bHLH protein, Olig2, is expressed selectively by motor neuron progenitors and has a key role in specifying the subtype identity and pan-neuronal properties of developing motor neurons. The role of Olig2 in the specification of motor neuron subtype identity depends on regulatory interactions with progenitor homeodomain proteins, whereas its role in promoting pan-neuronal properties is associated with expression of another bHLH protein, Ngn2. Both aspects of Olig2 function appear to depend an its activity as a transcriptional repressor. Together, these studies show that Olig2 has a critical role in integrating diverse features of motor neuron differentiation in the developing spinal cord.