Bone regeneration using recombinant human bone morphogenetic protein-2 (rhBMP-2) in alveolar defects of primate mandibles.
Bone regeneration using recombinant human bone morphogenetic protein-2 (rhBMP-2) in alveolar defects of primate mandibles.
复制标题
使用重组人骨形态发生蛋白 2 (rhBMP-2) 治疗灵长类下颌骨牙槽缺损的骨再生。
DOI：
10.1054/bjom.2001.0673
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
S. Enomoto
中科院分区：
文献类型：
--
作者：
E. Marukawa;I. Asahina;M. Oda;I. Seto;M. Alam;S. Enomoto
骨形态发生蛋白（bone morphogenetic protein， BMP）在骨重建中的作用已经在大量的动物实验中得到了广泛的研究，但关于其在灵长类动物中骨再生能力的研究尚不充分。本研究旨在探讨重组人BMP-2 （rhBMP-2）对幼龄灵长类动物下颌骨牙槽骨缺损成骨的影响。采用聚乳酸-羟基乙酸包被明胶海绵（PGS）渗透rhBMP-2植入9只5岁恒河猴下颌骨边缘骨缺损。术后12周切除骨经rhBMP-2处理后再生完全，组织学观察到新骨的重塑和巩固。本研究为非人类灵长类动物手术植入rhBMP-2后牙槽缺损的骨再生提供了证据。在临床实践中，该技术可能是自体骨移植重建手术的有效替代方法。
The efficacy of bone morphogenetic protein (BMP) for bone reconstruction has been widely studied in numerous animal experiments, but insufficient information exists about its ability to regenerate bone in primates. The purpose of this study was to evaluate the effects of recombinant human BMP-2 (rhBMP-2) on bone formation in alveolar bone defects in the mandibles of young primates. Marginal bone defects were created in the mandibles of nine 5-year-old rhesus monkeys and rhBMP-2 permeated in a polylactic-co-glycolic acid-coated gelatin sponge (PGS) was implanted into the bone defects. The resected bone treated with rhBMP-2 regenerated completely at 12 weeks postoperatively, and remodelling and consolidation of new bone were seen histologically. This study provides evidence of considerable bone regeneration in alveolar defects after surgical implantation of rhBMP-2 in non-human primates. This technique may be an effective alternative to autogenous bone grafts for reconstructive surgery in clinical practice.
影响因子：
1.8
作者：
U. Ripamonti;Barbara Van DenHeever;T. Sampath;M. Tucker;D. Rueger;A. Reddi
通讯作者：
U. Ripamonti;Barbara Van DenHeever;T. Sampath;M. Tucker;D. Rueger;A. Reddi