Position adjustment method and distance estimation method of magnetic field supply and detection unit for magnetic hyperthermia.
Position adjustment method and distance estimation method of magnetic field supply and detection unit for magnetic hyperthermia.
复制标题
磁热疗磁场供给和检测单元的位置调整方法和距离估计方法。
DOI：
10.1002/tee.22547
复制
发表时间：
2017
影响因子：
1
通讯作者：
Mitobe K
中科院分区：
文献类型：
--
作者：
Tonthat L;Aki F;Matsuda E;Saito H;Yoshimura N;Mitobe K
在磁热疗中，铁磁植入物在肿瘤区域中的温度和定位对于确定治疗加热的有效性至关重要。我们已经开发了一种无创无线测温方法，利用低居里温度（FILCT）随温度变化的铁磁植入物的磁导率属性。在临床环境中，当将FILCT注射到肿瘤区域中时，预期FILCT的位置偏离加热线圈（驱动线圈）的中心轴。当其偏离时，施加到FILCT的磁通量密度降低，从而导致难以经由拾取线圈检测FILCT的温度和在恒定处理温度下加热FILCT。因此，为了将磁场供应和检测（MFSD）单元调整到FILCT的正上方，我们提出了通过参考对称地安装在驱动线圈内部的三个拾取线圈中感应的三个电压的位置调整方法。通过使用三个电压的平均值，我们还提出了一种方法来估计MFSD单元和FILCT之间的距离，这是无线测温和确定所施加的最佳能量所需的。所提出的方法进行了实验验证系统。
In magnetic hyperthermia, the temperature and localization of a ferromagnetic implant in a tumor region is vital in determining the effectiveness of therapeutic heating. We have developed a noninvasive wireless temperature measurement method by utilizing the magnetic permeability property of a ferromagnetic implant with low Curie temperature (FILCT) that varies with the temperature. In clinical settings, when the FILCT is injected into a tumor region, the position of the FILCT is expected to deviate from the central axis of the heating coil (drive coil). When it deviates, the magnetic flux density applied to the FILCT decreases, thus causing difficulty in detecting the temperature of FILCT via a pickup coil and heating of the FILCT at a constant treatment temperature. Therefore, to adjust the magnetic field supply and detection (MFSD) unit to be directly above the FILCT, we propose a position adjustment method by referring to three voltages induced in three pickup coils symmetrically installed inside the drive coil. By using the average value of the three voltages, we also propose a method to estimate the distance between the MFSD unit and the FILCT, which is required for wireless thermometry and determination of the optimal energy applied. The proposed methods are experimentally examined by a verification system.