THE MECHANISM OF THE CURATIVE ACTION OF ANTIPNEUMOCOCCUS SERUM.
THE MECHANISM OF THE CURATIVE ACTION OF ANTIPNEUMOCOCCUS SERUM.
复制标题
DOI：
10.1084/jem.22.4.457
复制
发表时间：
1915-10-01
影响因子：
15.3
通讯作者：
Bull, C G
中科院分区：
文献类型：
--
作者：
Bull, C G
活性抗肺炎球菌血清在体外和体内引起肺炎球菌凝集。显微镜下测定的抗血清引起凝集的稀释度远大于肉眼观察的结果。当将抗血清注射到患有肺炎球菌菌血症的兔子的循环中时，会导致双球菌从血液中迅速消失。这种消失是由于双球菌在体内瞬间聚集，并被肝、脾、肺和可能的其他器官清除。
An active antipneumococcus serum causes agglutination of pneumococci in vitro and in vivo. The antiserum acts in far greater dilution in causing agglutination as determined by the microscopic than by the macroscopic test. The antiserum when injected into the circulation of rabbits suffering from pneumococcus bacteremia causes a rapid disappearance of the diplococci from the blood. This disappearance is brought about by instantaneous clumping of the diplococci in vivo and the removal of the clumps by the liver, spleen, lungs, and possibly other organs.