Interleukin-17-Producing gd T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals
Interleukin-17-Producing gd T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals
复制标题
DOI：
--
复制
发表时间：
--
期刊：
影响因子：
--
通讯作者：
Bruno Martin;K. Hirota;D. Cua;B. Stockinger;M. Veldhoen
中科院分区：
文献类型：
--
作者：
Bruno Martin;K. Hirota;D. Cua;B. Stockinger;M. Veldhoen
gd T细胞是白细胞介素-17（IL-17）的天然来源，在适应性辅助性T细胞17（Th 17）反应的发展之前。在这里，我们表明，产生IL-17的T细胞受体gd（TCRgd）的T细胞与Th 17细胞共有的特征，如趋化因子受体6（CCR 6），维甲酸孤儿受体（RORgt），芳烃受体（AhR）和IL-23受体的表达。AhR在gd T细胞中的表达对于IL-22的产生是必需的，但对于最佳IL-17的产生不是必需的。与Th 17细胞相反，产生CCR 6 IL-17的gd T细胞表达Toll样受体TLR 1和TLR 2，以及dectin-1，但不表达TLR 4，并且可以直接与某些病原体相互作用，但不表达其他gd T细胞。这一过程被IL-23放大，导致扩增、IL-17产生增加和中性粒细胞的募集。因此，与IL-17产生相关的先天性受体表达表征了TCRgd T细胞作为有效的第一道防线的特征，其可以在Th 17细胞感测到细菌入侵之前很久就协调对病原体来源的以及环境信号的炎症反应。
gd T cells are an innate sourceof interleukin-17 (IL-17), preceding the development of the adaptive T helper 17 (Th17) cell response. Here we show that IL-17producing T cell receptor gd (TCRgd) T cells share characteristic features with Th17 cells, such as expression of chemokine receptor 6 (CCR6), retinoid orphan receptor (RORgt), aryl hydrocarbon receptor (AhR), and IL-23 receptor. AhR expression in gd T cells was essential for the production of IL-22 but not for optimal IL-17 production. In contrast to Th17 cells, CCR6IL-17-producing gd T cells, but not other gd T cells, express Toll-like receptors TLR1 and TLR2, as well as dectin-1, but not TLR4 and could directly interact with certain pathogens. This process was amplified by IL-23 and resulted in expansion, increased IL-17 production, and recruitment of neutrophils. Thus, innate receptor expression linked with IL-17 production characterizes TCRgd T cells as an efficient first line of defense that can orchestrate an inflammatory response to pathogen-derived as well as environmental signals long before Th17 cells have sensed bacterial invasion.