Intergenerational transmission of adverse childhood experiences via maternal depression and anxiety and moderation by child sex
Intergenerational transmission of adverse childhood experiences via maternal depression and anxiety and moderation by child sex
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DOI：
10.1017/s2040174418000648
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发表时间：
2019-02-01
影响因子：
1.7
通讯作者：
Singhal, N.
中科院分区：
文献类型：
--
作者：
Letourneau, N.;Dewey, D.;Singhal, N.
父母的不良童年经历（ACE）与后代的各种负面健康结果有关。人们对 ACE 传递给下一代的机制知之甚少。鉴于母亲的抑郁和焦虑与 ACE 相关并对儿童的行为产生负面影响，这些暴露可能是母亲 ACE 与儿童精神病理学之间的途径。儿童性别可能会改变这些关联。我们的目标是确定：(1) ACE 与儿童行为之间的关联，(2) 母亲的产前和产后抑郁和焦虑症状是否介导母亲 ACE 与儿童行为之间的关系，以及 (3) 这些关系是否受到儿童性别的调节。使用参加阿尔伯塔省妊娠结局和营养研究的 907 名儿童及其母亲的数据进行皮尔逊相关性和潜在路径分析。总体而言，母亲的 ACE 与围产期的焦虑和抑郁症状以及儿童的外化问题有关。此外，我们观察到母亲 ACE 与儿童通过母亲焦虑和抑郁产生的内化和外化问题之间存在间接关联。观察到性别差异，男孩表现出更容易受到母亲 ACE 通过焦虑和抑郁产生的间接影响。研究结果表明，孕产妇心理健康可能是孕产妇早期生活逆境传染给儿童（尤其是男孩）的一种机制。需要进一步的研究来确定对同时患有高 ACE 和心理健康问题的女性进行有针对性的干预是否可以预防或改善 ACE 对儿童行为精神病理学的影响。
Adverse childhood experiences (ACEs) of parents are associated with a variety of negative health outcomes in offspring. Little is known about the mechanisms by which ACEs are transmitted to the next generation. Given that maternal depression and anxiety are related to ACEs and negatively affect children's behaviour, these exposures may be pathways between maternal ACEs and child psychopathology. Child sex may modify these associations. Our objectives were to determine: (1) the association between ACEs and children's behaviour, (2) whether maternal symptoms of prenatal and postnatal depression and anxiety mediate the relationship between maternal ACEs and children's behaviour, and (3) whether these relationships are moderated by child sex. Pearson correlations and latent path analyses were undertaken using data from 907 children and their mothers enrolled the Alberta Pregnancy Outcomes and Nutrition study. Overall, maternal ACEs were associated with symptoms of anxiety and depression during the perinatal period, and externalizing problems in children. Furthermore, we observed indirect associations between maternal ACEs and children's internalizing and externalizing problems via maternal anxiety and depression. Sex differences were observed, with boys demonstrating greater vulnerability to the indirect effects of maternal ACEs via both anxiety and depression. Findings suggest that maternal mental health may be a mechanism by which maternal early life adversity is transmitted to children, especially boys. Further research is needed to determine if targeted interventions with women who have both high ACEs and mental health problems can prevent or ameliorate the effects of ACEs on children's behavioural psychopathology.