Protective effect of rutin against spatial memory impairment induced by trimethyltin in rats
Protective effect of rutin against spatial memory impairment induced by trimethyltin in rats
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DOI：
10.1016/j.nutres.2008.06.004
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发表时间：
2008-09-01
影响因子：
4.5
通讯作者：
Imai, Hideki
中科院分区：
文献类型：
--
作者：
Koda, Tomoko;Kuroda, Yoshiki;Imai, Hideki
芦丁是一种具有多种生物活性的类黄酮，对人体健康有益。三甲基锡是一种有毒的有机锡化合物，注射三甲基锡的大鼠是研究空间记忆障碍和海马神经退行性变的有效体内模型。观察芦丁对三甲基锡致大鼠空间记忆障碍和海马神经元损伤的保护作用。Morris水迷宫实验和组织学检查结果显示，单剂量三甲基锡（8.5 mg/kg）口服可导致大鼠空间记忆丧失和海马CA3锥体神经元广泛丧失。长期补充芦丁可显著逆转三甲基锡诱导的空间记忆障碍和海马CA3b区锥体神经元损伤，提示芦丁具有抗氧化作用。这些结果表明，饮食中的芦丁可能对伴有海马锥体神经元丧失的空间记忆障碍具有保护作用。(c) 2008爱思唯尔公司版权所有。
Rutin is a flavonoid with various biological activities that are beneficial to human health. Trimethyltin is a toxic organotin compound, and rats injected with trimethyltin serve as a useful in vivo model for studying spatial memory impairment and neurodegeneration in the hippocampus. The protective effect of rutin against the trimethyltin-induced spatial memory impairment and hippocampal neuron damage in rats was examined. Peroral administration of a single dose of trimethyltin (8.5 mg/kg) induced spatial memory loss and the extensive loss of CA3 pyramidal neurons in hippocampi, as indicated by the results of a Morris water maze task and histologic examination, respectively. Prolonged supplementation of rutin significantly reversed the trimethyltin-induced spatial memory impairment and the damage to pyramidal neurons in the hippocampal CA3b region, indicating an antioxidative effect of rutin. These results suggest that rutin in the diet may provide a protective effect against spatial memory impairment accompanied by hippocampal pyramidal neuron loss. (c) 2008 Elsevier Inc. All rights reserved.