Evaluation of thoracic tumors with 18F-FMT and 18F-FDG PET-CT: A clinicopathological study
Evaluation of thoracic tumors with 18F-FMT and 18F-FDG PET-CT: A clinicopathological study
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DOI：
10.1002/ijc.24034
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发表时间：
2009-03-01
影响因子：
6.4
通讯作者：
Mori, Masatomo
中科院分区：
文献类型：
--
作者：
Kaira, Kyoichi;Oriuchi, Noboru;Mori, Masatomo
L-[3-F-18]-α-甲基酪氨酸（F-18-FMT）是正电子发射断层扫描（PET）的氨基酸示踪剂。本研究的目的是确定与F-18-FDG PET相比，F-18-FMT PET-CT是否为术前诊断检查提供了额外的信息。对36例经组织学证实的支气管癌、6例良性病变和1例非典型类癌患者进行了F-18-FMT和F-18-FDG PET-CT检查。采用免疫组化法检测L型氨基酸转运蛋白1（LAT 1）、CD 98、Ki 67标记指数、VEGF、CD 31和CD 34的表达，并与PET示踪剂摄取量进行相关性分析。对于肺部恶性肿瘤的检测，F-18-FMT PET显示出84%的灵敏度，而F-18-FDG PET的灵敏度为89%（p = 0.736）。F-18-FMT PET-CT和F-18-FDG PET-CT分别与85%和68%的病理分期一致（p = 0.151）。18F-FMT摄取与LAT 1、CD 98、细胞增殖和血管生成密切相关。F-18-FMT PET诊断胸部肿瘤的特异性高于（F1）8-FDG PET。我们的研究结果表明，除了细胞增殖和血管生成外，LAT 1和CD 98的共表达与肺癌的进展和转移有关。(c)2008威利利斯公司
L-[3-F-18]-alpha-methyltyrosine (F-18-FMT) is an aminoacid tracer for positron emission tomography (PET). The aim of this study was to determine whether PET-CT with F-18-FMT provides additional information for the preoperative diagnostic workup as compared with F-18-FDG PET. PET-CT studies with F-18-FMT and F-18-FDG were performed as a part of the preoperative workup in 36 patients with histologically confirmed bronchial carcinoma, 6 patients with benign lesions and a patient with atypical carcinoid. Expression of L-type amino acid transporter 1 (LAT1), CD98, Ki67 labeling index, VEGF, CD31 and CD34 of the resected tumors were analyzed by immunohistochemical staining, and correlated with the uptake of PET tracers. For the detection of pulmonary malignant tumors, F-18-FMT PET exhibited a sensitivity of 84% whereas the sensitivity for F-18-FDG PET was 89% (p = 0.736). F-18-FMT PET-CT and F-18-FDG PET-CT agreed with pathological staging in 85 and 68%, respectively (p = 0.151). 18F-FMT uptake was closely correlated with LAT1, CD98, cell proliferation and angiogenesis. The specificity of F-18-FMT PET for diagnosing thoracic tumors was higher than that of (F1)8-FDG PET. Our results suggest that coexpression of LAT1 and CD98 in addition to cell proliferation and angiogenesis is relavant for the progression and metastasis of lung cancer. (c) 2008 Wiley-Liss, Inc.