The neural correlates of intermanual transfer
The neural correlates of intermanual transfer
复制标题
DOI：
10.1016/j.neuroimage.2021.118657
复制
发表时间：
2021-10-25
期刊：
影响因子：
5.7
通讯作者：
Carrera, Emmanuel
中科院分区：
文献类型：
--
作者：
Dirren, Elisabeth;Bourgeois, Alexia;Carrera, Emmanuel
S T R A C T动作学习的手间迁移是一种学习泛化形式，在日常生活的各种任务中具有行为优势。它也可能对单侧运动障碍患者的康复有用。人们对调节手间迁移的神经结构和认知过程知之甚少。先前的研究表明，初级运动皮质(M1)和辅助运动区(SMA)具有一定的作用。在这里，我们研究了手间传递的功能神经解剖学，特别强调了运动网络内以及运动区域和注意网络之间的功能连接，包括额顶执行控制网络和视觉注意网络。我们设计了一个手指敲击任务，让年轻、健康的受试者在核磁共振扫描仪中训练非优势左手。在行为上，序列学习的迁移在大多数情况下被观察到，与训练手的表现无关。采用广义心理生理交互作用分析方法研究了训练前后大脑皮质运动种子的功能连接模式。与训练后相比，迁移与训练前左侧运动前皮质与背侧注意网络(顶上皮质、左侧颞中回)和执行控制网络(右侧前额叶)内结构之间的连接强度有关。运动网络内连通性的变化，尤其是训练和未训练的M1之间，以及SMA和未训练的M1之间的变化，与训练后的转移相关。综上所述，这些结果表明，注意、执行和运动网络之间的相互作用可能支持导致迁移的过程，而在训练之后，迁移转化为运动网络中更高的连通性。
A B S T R A C T Intermanual transfer of motor learning is a form of learning generalization that leads to behavioral advantages in various tasks of daily life. It might also be useful for rehabilitation of patients with unilateral motor deficits. Little is known about neural structures and cognitive processes that mediate intermanual transfer. Previous studies have suggested a role for primary motor cortex (M1) and the supplementary motor area (SMA). Here, we investigated the functional neuroanatomy of intermanual transfer with a special emphasis on functional connectivity within the motor network and between motor regions and attentional networks, including the fronto-parietal executive control network and visual attention networks. We designed a finger tapping task, in which young, heathy subjects trained the non-dominant left hand in the MRI scanner. Behaviorally, transfer of sequence learning was observed in most cases, independently of the trained hand's performance. Pre-and post-training functional connectivity patterns of cortical motor seeds were investigated using generalized psychophysiological interaction analyses. Transfer was correlated with the strength of connectivity between the left premotor cortex and structures within the dorsal attention network (superior parietal cortex, left middle temporal gyrus) and executive control network (right prefrontal regions) during pre-training, relative to post-training. Changes in connectivity within the motor network, and more particularly between trained and untrained M1, as well as between the SMA and untrained M1, correlated with transfer after training. Together, these results suggest that the interplay between attentional, executive and motor networks may support processes leading to transfer, whereas, following training, transfer translates into increased connectivity within the motor network.