Sequencing of rhesus macaque Y chromosome clarifies origins and evolution of the DAZ (Deleted in AZoospermia) genes.
Sequencing of rhesus macaque Y chromosome clarifies origins and evolution of the DAZ (Deleted in AZoospermia) genes.
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DOI：
10.1002/bies.201200066
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发表时间：
2012-12
期刊：
影响因子：
4
通讯作者：
Page, David C.
中科院分区：
文献类型：
--
作者：
Hughes, Jennifer F.;Skaletsky, Helen;Page, David C.
Y染色体进化的研究经常强调基因丢失，但这种丢失已通过添加新基因来抵消。 DAZ 基因对人类精子发生至关重要，是由旧大陆猴子和猿类祖先的 Y 染色体获得的。我们和我们的同事最近对恒河猴 Y 染色体进行了测序，并将该序列与人类和黑猩猩的序列进行比较，使我们能够重建 DAZ 的大部分进化历史。我们报告说，DAZ 在大约 3600 万年前通过至少 1.1 兆碱基的常染色体 DNA 转座到达 Y 染色体。这种转座还为 Y 染色体带来了五个额外的基因，但所有五个基因随后都因突变或缺失而丢失。作为唯一幸存的基因，DAZ经历了广泛的重组，包括基因内扩增和基因复制，并且一直是黑猩猩谱系中正选择的目标。
Studies of Y chromosome evolution often emphasize gene loss, but this loss has been counterbalanced by addition of new genes. The DAZ genes, which are critical to human spermatogenesis, were acquired by the Y chromosome in the ancestor of Old World monkeys and apes. We and our colleagues recently sequenced the rhesus macaque Y chromosome, and comparison of this sequence to human and chimpanzee enables us to reconstruct much of the evolutionary history of DAZ. We report that DAZ arrived on the Y chromosome about 36 million years ago via the transposition of at least 1.1 megabases of autosomal DNA. This transposition also brought five additional genes to the Y chromosome, but all five genes were subsequently lost through mutation or deletion. As the only surviving gene, DAZ experienced extensive restructuring, including intragenic amplification and gene duplication, and has been the target of positive selection in the chimpanzee lineage.
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影响因子：
64.8
作者：
Hughes, Jennifer F.;Skaletsky, Helen;Brown, Laura G.;Pyntikova, Tatyana;Graves, Tina;Fulton, Robert S.;Dugan, Shannon;Ding, Yan;Buhay, Christian J.;Kremitzki, Colin;Wang, Qiaoyan;Shen, Hua;Holder, Michael;Villasana, Donna;Nazareth, Lynne V.;Cree, Andrew;Courtney, Laura;Veizer, Joelle;Kotkiewicz, Holland;Cho, Ting-Jan;Koutseva, Natalia;Rozen, Steve;Muzny, Donna M.;Warren, Wesley C.;Gibbs, Richard A.;Wilson, Richard K.;Page, David C.
通讯作者：
Page, David C.
影响因子：
5.8
作者：
Mayor, C;Brudno, M;Dubchak, I
通讯作者：
Dubchak, I
DOI：
10.1098/rstb.2000.0717
发表时间：
2000-11-29
影响因子：
6.3
作者：
Charlesworth, B;Charlesworth, D
通讯作者：
Charlesworth, D
影响因子：
3.5
作者：
Noordam, Michiel J.;Westerveld, G. Henrike;Repping, Sjoerd
通讯作者：
Repping, Sjoerd
影响因子：
9.8
作者：
Repping, S;Skaletsky, H;Rozen, S
通讯作者：
Rozen, S