The phagocytosis of mycoplasmas.
The phagocytosis of mycoplasmas.
复制标题
DOI：
10.1099/00222615-43-4-239
复制
发表时间：
1995-10
影响因子：
3
通讯作者：
A. Marshall;R. Miles;L. Richards
中科院分区：
文献类型：
--
作者：
A. Marshall;R. Miles;L. Richards
支原体主要被认为是细胞外寄生虫或粘膜表面的病原体，虽然最近的证据表明，某些物种可能会入侵宿主的支原体在疾病中的作用也正在重新评估，在最近的研究结果，将它们与其他传染性病原体，包括艾滋病毒，l？2，5-9脑膜炎双球菌。l1和衣原体。12* 13吞噬细胞，如巨噬细胞和多形核白细胞（PMNL），构成了抵抗侵入肺和泌尿生殖道的支原体的第一道防线。14巨噬细胞系的细胞在呼吸道和泌尿生殖道粘膜上巡逻，在支原体感染部位聚集。l~它们不仅执行效应器功能，例如受体介导的吞噬作用，15~ l 6，而且它们也是免疫系统的重要辅助细胞，参与抗原递呈和细胞因子的产生。“在炎症刺激后，PMNL（与外周血单核细胞一起）也被趋化因子招募到该区域，并在感染支原体的呼吸道、滑膜和软骨组织中大量聚集。因此，在感染开始时，这两种细胞类型是支原体免疫的主要介质;事实上，这种相互作用的结果可能决定疾病的后续进展。
Mycoplasmas are recognised primarily as extracellular parasites or pathogens of mucosal surfaces, although recent evidence suggests that certain species may invade host The role of mycoplasmas in disease is also being reassessed in the light of recent findings linking them with other infectious agents, including HIV, l? 2, 5-9 meningococci'o. l1 and chlamydiae. 12* l3Phagocytic cells, such as macrophages and polymorphonuclear leucocytes (PMNL), comprise the first line of defence against mycoplasmas invading the lung and genitourinary tract. 14 Cells of the macrophagemonocyte lineage patrol the respiratory and genitourinary mucosae, accumulating at sites of mycoplasma infe~ ti0n. l~ Not only do they carry out effector functions such as receptor-mediated phagocytosis, 15~ l6 but they are also important accessory cells of the immune system involved in antigen presentation and the production of cytokines." After an inflammatory stimulus, PMNL (together with peripheral blood monocytes) are also recruited to the area by chemotaxP and large numbers amass in respiratory, synovial and cartilaginous tissues infected with mycoplasma~.~~~~~ Thus, at the onset of infection, these two cell types are the main mediators of immunity to mycoplasmas; indeed, the outcome of this interaction may determine the subsequent progression of disease.