Survival analysis of patients with femoral metastases
Survival analysis of patients with femoral metastases
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DOI：
10.1002/jso.22061
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发表时间：
2012-02-01
影响因子：
2.5
通讯作者：
Ruggieri, Pietro
中科院分区：
文献类型：
--
作者：
Mavrogenis, Andreas F.;Pala, Elisa;Ruggieri, Pietro
背景以前的研究报道了股骨转移瘤患者的手术指征。然而，很少有研究分析的频谱股骨转移介绍。我们进行了这项研究，以评估股骨转移瘤患者的生存，并澄清股骨即将和实际病理fracture.Materials和方法的治疗：我们回顾性研究了110例股骨转移瘤患者从1995年至2010年的各种癌症治疗钉或切除和megaprostic重建。平均随访18个月。生存进行了分析，就不同的转移表现，性别，癌症类型，数量和位置的股骨转移，手术类型，和病理fracture.Results：单变量预测生存的病理骨折和手术类型，多变量预测只有病理骨折。生存率显着较高的患者切除钉，即将相比，实际骨折，孤立性转移和即将骨折，实际骨折切除治疗，股骨近端实际骨折和股骨远端即将骨折治疗与receivation.Conclusions：股骨转移瘤患者有更好的生存时，目前与即将相比，实际病理性骨折。虽然并发症发生率较高，但股骨近端和远端病理性骨折的患者可能受益于切除术。外科肿瘤学杂志2012; 105：135-141. (C)2011 Wiley Periodicals，Inc.
Background Previous studies reported on surgical indications for patients with femoral metastases. However, few studies analyzed the spectrum of femoral metastatic presentation. We performed this study to evaluate the survival of patients with femoral metastases, and clarify the treatment of femoral impending and actual pathological fractures.Materials and Methods: We retrospectively studied 110 patients with femoral metastases from various cancers treated with nailing or resection and megaprosthetic reconstruction from 1995 to 2010. The mean follow-up was 18 months. Survival was analyzed with respect to different metastatic presentations regarding gender, type of cancer, number, and location of femoral metastases, type of surgery, and pathological fracture.Results: Univariate predictors of survival were the pathological fracture and type of surgery; multivariate predictor was only the pathological fracture. Survival was significantly higher in patients with resection compared to nailing, impending compared to actual fracture, solitary metastasis and impending fracture, actual fracture treated with resection, proximal femoral actual fracture and distal femoral impending fracture treated with resection.Conclusions: Patients with femoral metastases have better survival when present with impending compared to actual pathological fracture. Although with a higher rate of complications, patients with pathological fractures of the proximal and distal femur may benefit from resection. J. Surg. Oncol. 2012; 105: 135-141. (C) 2011 Wiley Periodicals, Inc.