The association between hepatitis C virus genotype and human immunodeficiency virus disease progression in a cohort of hemophilic men
The association between hepatitis C virus genotype and human immunodeficiency virus disease progression in a cohort of hemophilic men
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DOI：
10.1093/infdis/175.1.164
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发表时间：
1997-01-01
影响因子：
6.4
通讯作者：
Lee, CA
中科院分区：
文献类型：
--
作者：
Sabin, CA;Telfer, P;Lee, CA
同时感染丙型肝炎病毒（HCV）和人类免疫缺陷病毒（HIV）的患者，其丙型肝炎病毒感染进展更快；然而，关于丙型肝炎病毒合并感染对艾滋病病情进展的影响却知之甚少。本研究评估了在一组血友病男性患者中，感染不同丙型肝炎病毒基因型与艾滋病病情进展及死亡之间的关联。感染1型丙型肝炎病毒的患者相较于感染其他类型的患者，发展为艾滋病（P = 0.009）和死亡（P = 0.007）的速度更快。这种影响在很大程度上与血清转化时的年龄、血友病诊断以及随访期间CD4细胞计数的变化无关。这些结果表明丙型肝炎病毒基因型与艾滋病病情进展之间存在关联，如果得到证实，这可能对同时感染艾滋病和丙型肝炎病毒的患者的治疗和护理具有重要意义。
Patients coinfected with both hepatitis C virus (HCV) and the human immunodeficiency virus (HIV) have more rapid progression of HCV infection; however. little is known about the effect of coinfection with HCV on the progression of HIV disease. This study assessed the association between infection with different HCV genotypes on progression to AIDS and death in a cohort of men with hemophilia. Patients infected with HCV type 1 experienced a more rapid progression to bath AIDS (P = .009) and death (P = .007) than did those infected with other types. This effect was largely independent of age at seroconversion, hemophilia diagnosis, and changes in CD4 cell count over the follow-up period. These results suggest an association between HCV genotype and progression of HIV disease, which, if confirmed, could have important implications for the treatment and care of patients coinfected with both HIV and HCV.