Choroidal Thickness in Healthy Japanese Subjects
Choroidal Thickness in Healthy Japanese Subjects
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DOI：
10.1167/iovs.09-4383
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发表时间：
2010-04-01
影响因子：
4.4
通讯作者：
Yasuno, Yoshiaki
中科院分区：
文献类型：
--
作者：
Ikuno, Yasushi;Kawaguchi, Kana;Yasuno, Yoshiaki
目的.研究日本健康受试者的后脉络膜厚度及其分布，以及与眼轴长度、屈光不正（RE）和年龄的相关性。采用原型高穿透光学相干断层扫描技术，使用1060 nm光源，对43名无眼部或全身症状的健康志愿者的86只眼睛进行了检查。排除高度近视眼（超过-6 D）或视网膜/脉络膜疾病。用自动验光仪测量等效球镜反射率，用部分相干干涉仪测量眼轴长度。平均脉络膜厚度在中央凹为354 +/- 111 μ m，上方为364 +/- 86 μ m，后方为345 +/- 108 μ m，鼻侧为227 +/- 532 μ m，颞侧为337 +/- 102 μ m。中心凹下脉络膜厚度显著大于鼻侧（P < 0.01）和颞侧（P < 0.05）脉络膜厚度，但与上级（P = 0.20）和下层（P = 0.17）脉络膜厚度无显著性差异。颞侧脉络膜明显厚于鼻侧脉络膜（P < 0.01），下脉络膜明显薄于上级脉络膜（P < 0.01）。中心凹脉络膜厚度与眼轴长度呈显著负相关（P < 0.05），与RE（P = 0.086）和年龄（P = 0.07）呈临界相关。年龄是影响脉络膜厚度的最重要因素（F = 20.86; P < 0.001），其次是RE（F = 5.37; P < 0.05），眼轴长度不是影响脉络膜厚度的显著因素（F = 1.47; P = 0.22）。脉络膜厚度的轮廓取决于其位置。RE、眼轴长度，尤其是年龄是评价脉络膜厚度的关键。（Invest Ophthalmol维斯科学。2010; 51：2173-2176）DOI：10.1167/iovs.09-4383
PURPOSE. To study posterior choroidal thickness and its profile based on location in healthy Japanese subjects and the correlation with axial length, refractive error (RE), and age.METHODS. Eighty-six eyes of 43 healthy volunteers with no ophthalmic or systemic symptoms were examined with prototype high-penetration optical coherence tomography using a 1060-nm light source. Eyes with high myopia (exceeding -6 D) or with retinal/choroidal disease were excluded. The spherical equivalent RE was measured by autorefractometry, and the axial length was measured by partial coherence inferometry.RESULTS. Mean choroidal thicknesses were 354 +/- 111 mu m at the fovea, 364 +/- 86 mu m superiorly, 345 +/- 108 mu m inferiorly, 227 +/- 532 mu m nasally, and 337 +/- 102 mu m temporally. Subfoveal choroidal thickness was significantly greater than nasal (P < 0.01) and temporal (P < 0.05) choroidal thickness; however, there was no significant difference compared with superior (P = 0.20) and inferior (P = 0.17) choroidal thickness. The temporal choroid was significantly (P < 0.01) thicker than the nasal choroid, and the inferior choroid was significantly (P < 0.01) thinner than the superior choroid. There was a significant negative correlation between foveal choroidal thickness and axial length (P < 0.05) but a borderline correlation with the RE (P = 0.086) and age (P = 0.07). Age was the factor that was most associated with the choroidal thickness (F = 20.86; P < 0.001), followed by RE (F = 5.37; P < 0.05); axial length was not a significant factor (F = 1.47; P = 0.22) by stepwise analysis.CONCLUSIONS. The profile of choroidal thickness depends on its location. RE, axial length, and especially age are critical for evaluation of choroidal thickness. (Invest Ophthalmol Vis Sci. 2010; 51: 2173-2176) DOI:10.1167/iovs.09-4383