A common RNA motif in the 3′ end of the genomes of astroviruses, avian infectious bronchitis virus and an equine rhinovirus
A common RNA motif in the 3′ end of the genomes of astroviruses, avian infectious bronchitis virus and an equine rhinovirus
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DOI：
10.1099/0022-1317-79-4-715
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发表时间：
1998-04-01
影响因子：
3.8
通讯作者：
Grinde, B
中科院分区：
文献类型：
--
作者：
Jonassen, CM;Jonassen, TO;Grinde, B
在鸡传染性支气管炎病毒、禽冠状病毒和马鼻病毒血清2型小核糖核酸病毒基因组的3'非编码区中，存在与人星状病毒基因组3'端第二个RNA茎环在序列和折叠方面都具有显著相似性的基序。在绵羊、猪和火鸡的星状病毒中也发现了这种基序，这表明它是所有星状病毒的共同特征。传染性支气管炎病毒中该基序的排列区域与一些哺乳动物冠状病毒中距3' poly（A）尾相同距离的连续RNA序列之间存在显著的同源性。这些观察结果表明，在这三个病毒家族中存在的基序是至少两个独立的RNA重组事件的结果。
In the 3' non-coding region of the genomes of infectious bronchitis virus, an avian coronavirus and the picornavirus equine rhinovirus serotype 2, there is a motif with remarkable similarity, both in sequence and folding, to the second RNA stem-loop from the 3' end of the genomes of human astroviruses. This motif was also found in astroviruses of sheep, pig and turkey, suggesting that it is a common feature of all astroviruses. The conserved nature of the motif indicates that there has been strong selection for its preservation, There is significant homology between the regions Ranking this motif in infectious bronchitis virus and a continuous RNA sequence at the same distance from the 3' poly(A) tail in some related mammalian coronaviruses. These observations suggest that the presence of the motif in these three viral families is the result of at least two separate RNA recombination events.