Risk of methicillin-resistant Staphylococcus aureus infection after previous infection or colonization
Risk of methicillin-resistant Staphylococcus aureus infection after previous infection or colonization
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DOI：
10.1086/345955
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发表时间：
2003-02-01
影响因子：
11.8
通讯作者：
Platt, R
中科院分区：
文献类型：
--
作者：
Huang, SS;Platt, R
评估定植或感染的住院患者发生耐甲氧西林金黄色葡萄球菌 (MRSA) 相关后遗症风险的研究尚未将随访时间延长至出院后的时期。我们确定了 209 名新确定携带 MRSA 的成年患者 18 个月的 MRSA 感染风险。 29% 的患者（60 名患者）随后出现 MRSA 感染（90 名感染者）。这些感染通常很严重。 28% 的感染（90 例中的 25 例）涉及菌血症，56%（90 例中的 50 例）涉及肺炎、软组织感染、骨髓炎或化脓性关节炎。 80% 的后续感染 MRSA 的患者（60 人中的 48 人）在新部位发生感染，49% 的新 MRSA 感染（90 人中的 44 人）在出院后首次出现感染。准确评估 MRSA 相关后遗症的风险需要出院后长期随访。
Studies evaluating the risk of methicillin-resistant Staphylococcus aureus (MRSA)-associated sequelae in colonized or infected inpatients have not extended follow-up into the period after discharge from the hospital. We determined the 18-month risk of MRSA infection among 209 adult patients newly identified as harboring MRSA. Twenty-nine percent of patients (60 patients) developed subsequent MRSA infections (90 infections). These infections were often severe. Twenty-eight percent of infections (25 of 90) involved bacteremia, and 56% (50 of 90) involved pneumonia, soft tissue infection, osteomyelitis, or septic arthritis. Eighty percent of patients (48 of 60) with subsequent MRSA infection developed the infection at a new site, and 49% of new MRSA infections (44 of 90) first became manifest after discharge from the hospital. Accurate assessment of the risk of MRSA-associated sequelae requires prolonged follow-up after discharge.