Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development
Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development
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DOI：
10.1016/s0014-5793(00)01247-3
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发表时间：
2000-03-03
期刊：
影响因子：
3.5
通讯作者：
Kusumi, A
中科院分区：
文献类型：
--
作者：
Dan, I;Watanabe, NM;Kusumi, A
一种新的生发中心激酶（GCK）家族激酶，畸形/NIKs相关激酶（MINK），已被克隆，其表达的特点是在几个组织和不同发育阶段的小鼠大脑。MINK编码1300个氨基酸的多肽，由N-末端激酶结构域、富含脯氨酸的中间区和C-末端GCK同源区组成。MINK的表达在小鼠脑的出生后发育过程中上调。MINK激活cJun N-末端激酶和p38通路。(C)2000年欧洲生物化学学会联合会。
A new germinal center kinase (GCK) family kinase, Misshapen/NIKs-related kinase (MINK), has been cloned and its expression has been characterized in several tissues and various developmental stages of the mouse brain. MINK encodes a 1300 amino acid polypeptide, consisting of an N-terminal kinase domain, a proline-rich intermediate region, and a C-terminal GCK homology region. The expression of MINK is up-regulated during the postnatal development of the mouse brain. MINK activates the cJun N-terminal kinase and the p38 pathways. (C) 2000 Federation of European Biochemical Societies.