Rotavirus-specific cytotoxic T lymphocytes passively protect against gastroenteritis in suckling mice
Rotavirus-specific cytotoxic T lymphocytes passively protect against gastroenteritis in suckling mice
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DOI：
10.1128/jvi.64.12.6325-6328.1990
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发表时间：
1990-12
影响因子：
5.4
通讯作者：
P. Offit
中科院分区：
文献类型：
--
作者：
P. Offit
从免疫动物过继转移脾淋巴细胞后，乳鼠可免受鼠轮状病毒诱导的胃肠炎。连续转移Thy 1（+）-耗尽或CD 8（+）-耗尽的淋巴细胞消除了对攻击的保护。(We先前发现从轮状病毒免疫的小鼠中去除Thy 1+或CD 8+淋巴细胞会降低体外轮状病毒特异性细胞毒活性。在乳鼠血清中不存在轮状病毒特异性中和抗体的情况下，发生了对疾病的保护。轮状病毒特异性细胞毒性T淋巴细胞可能在缓解急性感染或防止再感染中起重要作用。
Suckling mice are protected against murine rotavirus-induced gastroenteritis after adoptive transfer of splenic lymphocytes from immunized animals. Adoptive transfer of Thy1(+)-depleted or CD8(+)-depleted lymphocytes abrogated protection against challenge. (We previously found that depletion of Thy1+ or CD8+ lymphocytes from rotavirus-immunized mice decreased rotavirus-specific cytotoxic activity in vitro.) Protection against disease occurred in the absence of rotavirus-specific neutralizing antibodies in the sera of suckling mice. Rotavirus-specific cytotoxic T lymphocytes may be important in either amelioration of acute infection or protection against reinfection.