Relationship between lipid abnormalities and insulin resistance in Japanese school children
Relationship between lipid abnormalities and insulin resistance in Japanese school children
复制标题
DOI：
10.1161/01.atv.0000245804.56871.31
复制
发表时间：
2006-12-01
影响因子：
8.7
通讯作者：
Ohta, Takao
中科院分区：
文献类型：
--
作者：
Asato, Yoshihide;Katsuren, Keisuke;Ohta, Takao
目的 - 血脂异常和胰岛素抵抗 (IR) 是成人冠心病 (CHD) 的危险因素。为了帮助预防 CHD 的发展，了解儿童时期脂质异常与 IR 之间的关系可能会有所帮助。方法和结果 - IR 通过稳态模型近似指数进行评估。我们研究了 1175 名日本学童（642 名男孩和 533 名女孩），年龄在 7 至 12 岁之间。肥胖由体重指数标准差评分 (BMISD) 定义（肥胖：BMISD >= 2.0）。在非肥胖儿童中，BMISD 与 IR 的相关性最为显着 (P = 0.000)。 IR 与脂质相关参数的关联受到 BMISD 的影响。经过BMISD校正后，在非肥胖儿童中，男孩的log甘油三酯（TG）、apoB和低密度脂蛋白（LDL）大小以及女孩的log TG、LDL大小和高密度脂蛋白（HDL）胆固醇仍然与IR显着相关（P = 0.000至0.017）。在肥胖儿童中，除男孩 LDL 胆固醇和女孩 LDL 大小外，所有参数均与 IR 显着相关（P = 0.000 至 0.030）。多元回归分析显示，非肥胖儿童的 log TG 和 LDL 大小、肥胖男孩的 log TG 和肥胖女孩的 LDL 大小与 IR 独立相关。即使在校正 BMISD 和年龄后，患有 IIb 和 IV 级高脂血症的儿童的 IR 也显着高于患有正常脂血症和 IIa 的儿童。结论 - 我们的结果表明，除了控制体重之外，对于学龄儿童来说，表征脂质表型对于预防进展为 CHD 和/或 2 型糖尿病以及识别患有这些疾病的高风险受试者可能也很重要。
Objective - Dyslipidemia and insulin resistance (IR) are risk factors for coronary heart disease (CHD) in adults. To help prevent the development of CHD, it may be useful to understand the relationship between lipid abnormalities and IR during childhood.Methods and Results - IR was assessed by the homeostasis model approximation index. We studied 1175 Japanese school children (642 boys and 533 girls), aged between 7 and 12 years. Obesity was defined by the body mass index standard deviation score (BMISD) (obese: BMISD >= 2.0). BMISD was most significantly associated with IR in nonobese children (P = 0.000). Associations of IR with lipid-related parameters were affected by BMISD. After being corrected by BMISD, in nonobese children, log triglycerides (TG), apoB and low-density lipoprotein (LDL) size in boys and log TG, LDL size, and high-density lipoprotein (HDL) cholesterol in girls were still significantly associated with IR (P = 0.000 to 0.017). In obese children, all parameters except for LDL cholesterol in boys and LDL size in girls were significantly associated with IR (P = 0.000 to 0.030). Multiple regression analysis showed that log TG and LDL size in nonobese children, log TG in obese boys and LDL size in obese girls were independently associated with IR. Children with IIb and IV hyperlipidemia had significantly higher IR than those with normolipidemia and IIa, even after correcting for BMISD and age.Conclusion - Our results suggest that in addition to controlling body weight, it may be important for school children to characterize lipid phenotypes to prevent progression to CHD and/or type 2 diabetes and to identify subjects who are at high risk for these disorders.