A Novel Transgenic Mouse Model of the Human Multiple Myeloma Chromosomal Translocation t(14;16)(q32;q23)
A Novel Transgenic Mouse Model of the Human Multiple Myeloma Chromosomal Translocation t(14;16)(q32;q23)
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DOI：
10.1158/0008-5472.can-10-1057
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发表时间：
2011-01-15
期刊：
影响因子：
11.2
通讯作者：
Takahashi, Satoru
中科院分区：
文献类型：
--
作者：
Morito, Naoki;Yoh, Keigyou;Takahashi, Satoru
多发性骨髓瘤（MM）是一种目前无法治愈的终末分化B细胞肿瘤。虽然c-MAF可能在人MM中作为癌基因发挥作用，但迄今为止还没有报道描述c-MAF过表达在体内直接诱导MM。在这项研究中，我们已经产生了转基因（TG）小鼠表达c-Maf特异性的B细胞室。老年c-Maf TG小鼠发生B细胞淋巴瘤，具有与MM相似的一些临床特征，即浆细胞扩增和高球蛋白血症。定量RTPCR分析表明，Ccnd 2和Itgb 7，这是已知的c-Maf的靶基因，在淋巴瘤细胞中的高表达。这种新的人MM t（14;16）（q32;q23）染色体易位的TG小鼠模型应该为c-MAF在肿瘤发生中的作用提供新的见解。Cancer Res; 71（2）; 339-48. (C)2011年AACR。
Multiple myeloma (MM) is a currently incurable neoplasm of terminally differentiated B cells. The translocation and/or overexpression of c-MAF have been observed in human MM. Although c-MAF might function as an oncogene in human MM, there has been no report thus far describing the direct induction of MM by c-MAF overexpression in vivo. In this study, we have generated transgenic (TG) mice that express c-Maf specifically in the B-cell compartment. Aged c-Maf TG mice developed B-cell lymphomas with some clinical features that resembled those of MM, namely, plasma cell expansion and hyperglobulinemia. Quantitative RTPCR analysis demonstrated that Ccnd2 and Itgb7, which are known target genes of c-Maf, were highly expressed in the lymphoma cells. This novel TG mouse model of the human MM t(14;16)(q32;q23) chromosomal translocation should serve to provide new insight into the role of c-MAF in tumorigenesis. Cancer Res; 71(2); 339-48. (C) 2011 AACR.