Stimulus Repetition Probability Does Not Affect Repetition Suppression in Macaque Inferior Temporal Cortex
Stimulus Repetition Probability Does Not Affect Repetition Suppression in Macaque Inferior Temporal Cortex
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DOI：
10.1093/cercor/bhq207
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发表时间：
2011-07-01
期刊：
影响因子：
3.7
通讯作者：
Vogels, Rufin
中科院分区：
文献类型：
--
作者：
Kaliukhovich, Dzmitry A.;Vogels, Rufin
最近的人类功能磁共振成像研究（Summerfield C，Trittschuh EH，Monti JM，Mesulam MM，Egner T.2008。神经重复抑制反映了知觉期望的满足。Nat Neurosci.11：1004-1006。）表明适应或重复抑制受到与知觉期望相关的背景因素的影响，表明适应是知觉期望的满足或预测误差减少的结果。这种观点与单细胞研究中提出的自下而上的疲劳或适应锐化机制形成鲜明对比。我们使用类似于 Summerfield 等人的协议，检查了刺激重复概率是否影响猕猴下颞叶 (IT) 皮层的尖峰活动和局部场电位 (LFP) 的适应。猴子接受了 2 个随机交错的试验，每个试验由 2 个相同的刺激（重复试验）或 2 个不同的刺激（替代试验）组成。试验以由 75% 的重复试验和 25% 的替代试验组成的重复 (rep) 块或具有相反重复概率的交替 (alt) 块进行。对于尖峰和 LFP 活动，重复块和替代块之间的刺激选择性适应没有显着差异。之前的代表或替代试验的数量以及块内的试验位置不会影响适应。刺激重复概率对适应没有任何影响表明信息技术的适应不是由与知觉期望相关的情境因素引起的。
Recent human functional magnetic resonance imaging studies (Summerfield C, Trittschuh EH, Monti JM, Mesulam MM, Egner T. 2008. Neural repetition suppression reflects fulfilled perceptual expectations. Nat Neurosci. 11:1004-1006.) showed that adaptation or repetition suppression is affected by contextual factors related to perceptual expectations, suggesting that adaptation results from a fulfillment of perceptual expectation or a reduction in prediction error. This view contrasts with the bottom-up fatigue or sharpening mechanisms of adaptation proposed in single-cell studies. We examined whether stimulus repetition probability affects adaptation of spiking activity and local field potentials (LFPs) in macaque inferior temporal (IT) cortex, using a protocol similar to that of Summerfield et al. Monkeys were exposed to 2 randomly interleaved trials, each consisting of either 2 identical (rep trial) or 2 different stimuli (alt trial). Trials were presented in repetition (rep) blocks consisting of 75% of rep trials and 25% of alt trials or in alternation (alt) blocks having opposite repetition probabilities. For both spiking and LFP activities, the stimulus-selective adaptation did not differ significantly between rep and alt blocks. The number of preceding rep or alt trials and the trial position within a block did not affect adaptation. This absence of any effect of stimulus repetition probability on adaptation suggests that adaptation in IT is not caused by contextual factors related to perceptual expectation.