Decreased prevalence of left-handedness among females with male co-twins: evidence suggesting prenatal testosterone transfer in humans?
Decreased prevalence of left-handedness among females with male co-twins: evidence suggesting prenatal testosterone transfer in humans?
复制标题
有男性双胞胎的女性左撇子患病率降低：证据表明人类产前睾酮转移？
DOI：
10.1016/j.psyneuen.2010.04.013
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发表时间：
2010
影响因子：
3.7
通讯作者：
Kaprio,Jaakko
中科院分区：
文献类型：
--
作者：
Vuoksimaa,Eero;Eriksson,CJPeter;Pulkkinen,Lea;Rose,RichardJ;Kaprio,Jaakko
对单身人士的研究表明，右撇子的睾丸激素水平可能高于左撇子。产前睾酮水平被假设为是特别相关的偏手性的形成。在人类中，来自异性双胞胎对的女性成员可能会在与男性共享的宫内环境中经历产前睾酮暴露水平升高。我们测试了同性和异性双胞胎中女性双胞胎的左利手/右利手比率的差异。我们的样本包括4736名受试者，约70%的芬兰双胞胎出生于1983-1987年，测量怀孕和出生相关因素的信息。在这些双胞胎中，分别有771人和744人在14岁时的循环睾酮和雌二醇水平。我们发现，与同性配对的女性（8.6%）相比，异性配对的女性（5.3%）左撇子的患病率显著（p<0.006）较低。无论是男性还是女性，循环中的睾酮和雌二醇水平都与利手无关。异性双胞胎和同性双胞胎的女性之间的循环睾酮或雌二醇水平也没有差异。出生和怀孕的相关因素，我们有信息无关的利手。我们的研究结果很难用出生后的因素来完全解释，但它们为将睾酮与偏手性形成联系起来的理论提供了支持，并且在基于人群的样本中，提示了产前睾酮转移的影响。
Studies of singletons suggest that right-handed individuals may have higher levels of testosterone than do left-handed individuals. Prenatal testosterone levels are hypothesised to be especially related to handedness formation. In humans, female members from opposite-sex twin pairs may experience elevated level of prenatal exposure to testosterone in their intrauterine environment shared with a male. We tested for differences in rates of left-handedness/right-handedness in female twins from same-sex and opposite-sex twin pairs. Our sample consisted of 4736 subjects, about 70% of all Finnish twins born in 1983–1987, with information on measured pregnancy and birth related factors. Circulating testosterone and estradiol levels at age 14 were available on 771 and 744 of these twins, respectively. We found significantly (p<.006) lower prevalence of left-handedness in females from opposite-sex pairs (5.3%) compared to females from same-sex pairs (8.6%). The circulating levels of neither testosterone nor estradiol related to handedness in either females or males. Nor were there differences in circulating testosterone or estradiol levels between females from opposite-sex and same-sex twin pairs. Birth and pregnancy related factors for which we had information were unrelated to handedness. Our results are difficult to fully explain by postnatal factors, but they offer support to theory that relates testosterone to formation of handedness, and in a population-based sample, are suggestive of effects of prenatal testosterone transfer.