The head direction cell system and behavior: The effects of lesions to the lateral mammillary bodies on spatial memory in a novel landmark task and in the water maze.
The head direction cell system and behavior: The effects of lesions to the lateral mammillary bodies on spatial memory in a novel landmark task and in the water maze.
复制标题
DOI：
10.1037/bne0000106
复制
发表时间：
2015-12
影响因子：
1.9
通讯作者：
Dudchenko PA
中科院分区：
文献类型：
--
作者：
Harland B;Wood ER;Dudchenko PA
头部方向系统由许多相互连接的大脑区域中的神经元组成，这些神经元以急剧调整的定向方式放电。然而，该系统的功能尚未完全确定。为了评估这一点，我们设计了一种新颖的空间标志任务，与评估空间调谐神经元刺激控制的范例相当。该任务在一个大圆柱体中进行，要求老鼠从 16 个选项中挖掘特定的沙杯，以获得食物奖励。加固的杯子位于相对于显着地标的固定位置，探测过程证实该地标对大鼠的杯子选择施加刺激控制。为了评估头部方向细胞系统对这项记忆任务的贡献，一半的动物接受了鹅黄酸输注到外侧乳头核（LMN），这是头部方向网络的重要节点，而另一只动物则接受了假损伤。两组之间在这项任务的表现上没有观察到差异。然而，患有 LMN 损伤的动物在水迷宫任务的逆向学习中受到损害。这些结果表明，LMN 以及潜在的头部方向细胞系统对于使用视觉标志来引导空间行为并不是必需的。
The head direction system is composed of neurons found in a number of connected brain areas that fire in a sharply tuned, directional way. The function of this system, however, has not been fully established. To assess this, we devised a novel spatial landmark task, comparable to the paradigms in which stimulus control has been assessed for spatially tuned neurons. The task took place in a large cylinder and required rats to dig in a specific sand cup, from among 16 alternatives, to obtain a food reward. The reinforced cup was in a fixed location relative to a salient landmark, and probe sessions confirmed that the landmark exerted stimulus control over the rats’ cup choices. To assess the contribution of the head direction cell system to this memory task, half of the animals received ibotenic acid infusions into the lateral mammillary nuclei (LMN), an essential node in the head direction network, while the other received sham lesions. No differences were observed in performance of this task between the 2 groups. Animals with LMN lesions were impaired, however, in reversal learning on a water maze task. These results suggest that the LMN, and potentially the head direction cell system, are not essential for the use of visual landmarks to guide spatial behavior.