Neutrophils play a critical role in early resistance to amebic liver abscesses in severe combined immunodeficient mice.
Neutrophils play a critical role in early resistance to amebic liver abscesses in severe combined immunodeficient mice.
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中性粒细胞在严重联合免疫缺陷小鼠对阿米巴肝脓肿的早期抵抗中发挥着关键作用。
DOI：
10.1128/iai.65.9.3951-3953.1997
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发表时间：
1997
影响因子：
3.1
通讯作者：
StanleyJr,SL
中科院分区：
文献类型：
--
作者：
Seydel,KB;Zhang,T;StanleyJr,SL
溶组织内阿米巴形成肝脓肿的动物模型表明，中性粒细胞是宿主免疫系统与入侵的阿米巴相互作用的第一个细胞。体外研究表明，嗜中性粒细胞的裂解毒力阿米巴可能会加剧阿米巴肝脓肿的损害。为了研究中性粒细胞在体内的作用，我们使用阿米巴肝脓肿形成的严重联合免疫缺陷（SCID）小鼠模型，并比较中性粒细胞缺失和对照组小鼠的肝损伤。我们发现中性粒细胞缺失的动物在感染的早期阶段有明显更大的阿米巴肝脓肿，并且中性粒细胞缺失的SCID小鼠的脓肿缺乏对照SCID小鼠阿米巴肝脓肿中明显的炎症细胞环。这些数据表明，中性粒细胞在早期宿主对肝脏阿米巴感染的反应中起保护作用。
Animal models of liver abscess formation with Entamoeba histolytica suggest that the neutrophil is the first cell of the host immune system to interact with the invading ameba. In vitro studies have suggested that lysis of neutrophils by virulent amebae may exacerbate the damage seen in amebic liver abscesses. To investigate the role of neutrophils in vivo, we used the severe combined immunodeficient (SCID) mouse model of amebic liver abscess formation and compared liver damage in neutrophil-depleted and control mice. We found that neutrophil-depleted animals have significantly larger amebic liver abscesses at early stages of infection and that abscesses in neutrophil-depleted SCID mice lack the prominent inflammatory cell ring seen in amebic liver abscesses in control SCID mice. These data suggest that neutrophils play a protective role in the early host response to amebic infection of the liver.