The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003
The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003
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DOI：
10.1093/nar/gkg095
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发表时间：
2003-01-01
影响因子：
14.9
通讯作者：
Schneider, M
中科院分区：
文献类型：
--
作者：
Boeckmann, B;Bairoch, A;Schneider, M
SWISS-PROT蛋白知识库（http：/ / www. expasy。org/ sprot/和http：/ / www. ebi AC. uk/ swissprot/）将氨基酸序列与生命科学中的现有知识联系起来。每个蛋白质条目通过汇集实验结果，计算特征，有时甚至是相互矛盾的结论，提供了相关信息的跨学科概述。通过与专业数据库的直接链接，可以获得超出SWISS-PROT范围的详细专业知识。SWISS-PROT提供了所有物种的注释条目，但集中于人类（HPI项目）和其他模式生物的条目注释，以确保所有蛋白质家族代表性成员的高质量注释。部分注释可以转移到其他家族成员，正如微生物蛋白质组高质量自动和手动注释（HAMAP）项目已经为微生物所做的那样。蛋白质家族和蛋白质组定期进行审查，以跟上当前的科学发现。作为补充，TrEMBL努力包含SWISS-PROT中尚未表示的所有蛋白质序列，通过纳入不断增加的自动化注释水平。欢迎研究人员通过将相关发现提交给SWISS-PROT（swiss-prot@expasy.org），为科学界贡献他们的知识。
The SWISS-PROT protein knowledgebase (http: / / www. expasy. org/ sprot/ and http: / / www. ebi. ac. uk/ swissprot/) connects amino acid sequences with the current knowledge in the Life Sciences. Each protein entry provides an interdisciplinary overview of relevant information by bringing together experimental results, computed features and sometimes even contradictory conclusions. Detailed expertise that goes beyond the scope of SWISS-PROT is made available via direct links to specialised databases. SWISS-PROT provides annotated entries for all species, but concentrates on the annotation of entries from human ( the HPI project) and other model organisms to ensure the presence of high quality annotation for representative members of all protein families. Part of the annotation can be transferred to other family members, as is already done for microbes by the High-quality Automated and Manual Annotation of microbial Proteomes (HAMAP) project. Protein families and groups of proteins are regularly reviewed to keep up with current scientific findings. Complementarily, TrEMBL strives to comprise all protein sequences that are not yet represented in SWISS-PROT, by incorporating a perpetually increasing level of mostly automated annotation. Researchers are welcome to contribute their knowledge to the scientific community by submitting relevant findings to SWISS-PROT at swiss-prot@expasy.org.