Local hyperthermia in head and neck cancer: mechanism, application and advance.
Local hyperthermia in head and neck cancer: mechanism, application and advance.
复制标题
头颈癌局部热疗的机制、应用及进展
DOI：
10.18632/oncotarget.10350
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发表时间：
2016-08-30
期刊：
影响因子：
--
通讯作者：
Liang X
中科院分区：
文献类型：
--
作者：
Gao S;Zheng M;Ren X;Tang Y;Liang X
局部热疗，特别是与手术、放疗和化疗相结合，对包括头颈癌在内的人类恶性肿瘤的治疗是非常有用的。然而，目前它受到许多限制，如热剂量控制、靶向治疗区域以及对健康细胞和癌细胞的区分等。纳米技术的最新发展将新型和智能的治疗纳米材料引入到头颈癌的局部HT中，这些材料基本上利用了各种靶向方法。本文就头颈部肿瘤局部热疗的机制、方法及临床应用作一综述，重点介绍光热疗法和纳米粒子热疗。
Local hyperthermia (HT), particularly in conjunction with surgery, radiotherapy and chemotherapy was useful for the treatment of human malignant tumors including head and neck cancer. However, at present it suffered from many limitations such as thermal dose control, target treatment regions and discrimination between healthy and cancer cells. Recent developments in nanotechnology have introduced novel and smart therapeutic nanomaterials to local HT of head and neck cancer that basically take advantage of various targeting approaches. The aim of this paper is to give a brief review of the mechanism, methods and clinical applications of local HT in head and neck cancer, mainly focusing on photothermal therapy (PTT) and nanoparticle-based hyperthermia.