Genetic diversity at class II DRB loci of the primate MHC.
Genetic diversity at class II DRB loci of the primate MHC.
复制标题
灵长类 MHC II 类 DRB 位点的遗传多样性。
DOI：
--
复制
发表时间：
1991
影响因子：
4.4
通讯作者：
Henry A. Erlich
中科院分区：
文献类型：
--
作者：
Ulf Gyllensten;M. Sundvall;I. Ezcurra;Henry A. Erlich
通过DNA扩增（聚合酶链反应）研究了灵长类动物中编码MHC II类DR Ag β链的基因座多态性的演变。对来自非人灵长类动物多态性第二外显子（第一结构域）的63个DRB序列和53个人类序列的系统发育分析表明，灵长类动物中存在5个DRB基因座，来自2000万年前的DRB 1样祖先基因座。DRB 1基因座上的许多等位基因类型早于类人猿的分化（500万年前），有些（DR 4、DR 3、5、6）早于旧大陆猴和类人猿的分化（2000万年前）。DRB 3基因座似乎出现在原始人类在祖先DRB 1谱系上的分歧之前。DRB 2和DRB 5基因座产生于2000万年前，DRB 4基因座产生于500万年前。DRB 2基因座是人类的假基因，在非人灵长类动物中具有多态性。
The evolution of polymorphism at loci encoding the beta-chains of the MHC class II DR Ag was studied in primates by DNA amplification (polymerase chain reaction). Phylogenetic analysis of 63 DRB sequences from the polymorphic second exon (first domain) of nonhuman primates and 53 human sequences indicates the presence of five DRB loci in primates, derived from a DRB1-like ancestral locus over 20 million yr ago. Many of the allelic types at the DRB1 locus predate the divergence of hominoids (5 million yr ago) and some (DR4, DR3, 5, 6) predate the divergence of Old world monkeys and hominoids (20 million yr ago). The DRB3 locus appears to have arisen before the divergence of hominoids on an ancestral DRB1 lineage. The DRB2 and DRB5 loci were generated more than 20 million yr ago and the DRB4 locus more than 5 million yr ago. The DRB2 locus, a pseudogene in humans, is polymorphic in the nonhuman primates.