Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4
Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4
复制标题
DOI：
10.1016/j.bbrc.2009.09.015
复制
发表时间：
2009-12-25
影响因子：
3.1
通讯作者：
Kawahara, Ko-ichi
中科院分区：
文献类型：
--
作者：
Kikuchi, Kiyoshi;Tancharoen, Salunya;Kawahara, Ko-ichi
水通道蛋白4（AQP4）在缺血后水肿的产生中起作用，因此对AQP4功能的药理学调节可能为治疗中风、肿瘤相关水肿、癫痫、创伤性脑损伤以及其他与脑水平衡改变相关的中枢神经系统（CNS）疾病提供一种新的治疗策略。依达拉奉是一种自由基清除剂，在日本用于治疗急性缺血性中风（AIS）。在本研究中，在大鼠短暂性局灶性缺血模型中，依达拉奉在再灌注24小时后显著减小了梗死面积并改善了神经功能缺损评分。此外，依达拉奉显著降低了脑梗死区域的AQP4免疫反应性和蛋白质水平。鉴于在大鼠短暂性局灶性缺血模型中观察到依达拉奉特异性抑制AQP4，我们提出依达拉奉可能通过抑制脑梗死后AQP4的表达来减轻脑水肿。（C）2009爱思唯尔公司。保留所有权利。
Aquaporin-4 (AQP4) plays a role in the generation of post-ischemic edema, Pharmacological modulation of AQP4 function may thus provide a novel therapeutic strategy for the treatment of stroke, tumor-associated edema, epilepsy, traumatic brain injury, and other disorders of the central nervous system (CNS) associated with altered brain water balance. Edaravone, a free radical scavenger, is used for the treatment of acute ischemic stroke (AIS) in Japan. In this study, edaravone significantly reduced the infarct area and improved the neurological deficit scores at 24 h after reperfusion in a rat transient focal ischemia model. Furthermore, edaravone markedly reduced AQP4 immunoreactivity and protein levels in the cerebral infarct area. In light of observations that edaravone specifically inhibited AQP4 in a rat transient focal ischemia model, we propose that edaravone might reduce cerebral edema through the inhibition of AQP4 expression following cerebral infarction. (C) 2009 Elsevier Inc. All rights reserved.