A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer.
A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer.
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发表时间：
2015-03
影响因子：
2
通讯作者：
T. Iguchi;R. Uchi;Sho Nambara;Tomoko Saito;H. Komatsu;H. Hirata;M. Ueda;S. Sakimura;Yuki Takano-Yuki
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文献类型：
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作者：
T. Iguchi;R. Uchi;Sho Nambara;Tomoko Saito;H. Komatsu;H. Hirata;M. Ueda;S. Sakimura;Yuki Takano-Yuki
背景与目的近年来发现一种由转化生长因子β（TGF-β）激活的长链非编码RNA（lncRNA-ATB）参与肝细胞癌的侵袭-转移级联反应。本研究的目的是阐明lncRNA-ATB在结直肠癌（CRC）中的临床病理作用和预后相关性。材料与方法采用实时逆转录聚合酶链反应检测124例结直肠癌患者lncRNA-ATB的表达。根据中位lncRNA-ATB表达将患者分为两组。结果lncRNA-ATB高表达与肿瘤大小、浸润深度、淋巴管浸润、血管浸润和淋巴结转移显著相关。高lncRNA-ATB表达组患者的预后明显差于低表达组。此外，lncRNA-ATB表达水平在血行转移患者中显著更高。结论lncRNA-ATB可能参与结直肠癌的发生发展，并可能成为结直肠癌患者预后不良的新指标。
BACKGROUND/AIM A long noncoding RNA (lncRNA) activated by transforming growth factor (TGF)-β (lncRNA-ATB) was recently described to promote the invasion-metastasis cascade in hepatocellular carcinoma. The aim of the present study was to clarify the clinicopathological role and prognostic relevance of lncRNA-ATB in colorectal cancer (CRC). MATERIALS AND METHODS lncRNA-ATB expression was evaluated by real-time reverse transcription polymerase chain reaction in 124 patients with CRC. Patients were divided into two groups based on the median lncRNA-ATB expression. RESULTS High lncRNA-ATB expression was significantly associated with greater tumor size, depth of tumor invasion, lymphatic invasion, vascular invasion, and lymph node metastasis. Patients of the high-lncRNA-ATB expression group had significantly poorer outcomes than those of the low-expression group. Additionally, levels of lncRNA-ATB expression were significantly higher in patients with hematogenous metastases. CONCLUSION lncRNA-ATB may be involved in the progression of CRC and be a novel indicator of poor prognosis in patients with CRC.