Autoantibody-dependent and autoantibody-independent roles for B cells in systemic lupus erythematosus: past, present, and future.
Autoantibody-dependent and autoantibody-independent roles for B cells in systemic lupus erythematosus: past, present, and future.
复制标题
DOI：
10.3109/08916930903374600
复制
发表时间：
2010-02
期刊：
影响因子：
3.5
通讯作者：
Stohl W
中科院分区：
文献类型：
--
作者：
Jacob N;Stohl W
It has long been known that B cells produce autoantibodies and, thereby, contribute to the pathogenesis of many autoimmune diseases. Systemic lupus erythematosus (SLE), a prototypic systemic autoimmune disorder, is characterized by high circulating autoantibody titers and immune-complex deposition that can trigger inflammatory damage in multiple organs/organ systems. Although the interest in B cells in SLE has historically focused on their autoantibody production, we now appreciate that B cells have multiple autoantibody-independent roles in SLE as well. B cells can efficiently present antigen and activate T cells, they can augment T cell activation through co-stimulatory interactions, and they can produce numerous cytokines which affect inflammation, lymphogenesis, and immune regulation. Not surprisingly, B cells have become attractive therapeutic targets in SLE. With these points in mind, this review will focus on the autoantibody-dependent and autoantibody-independent roles for B cells in SLE and on therapeutic approaches that target B cells.
登录
查看更多内容
DOI：
10.4049/jimmunol.0803052
发表时间：
2009-03-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Blair PA;Chavez-Rueda KA;Evans JG;Shlomchik MJ;Eddaoudi A;Isenberg DA;Ehrenstein MR;Mauri C
通讯作者：
Mauri C
影响因子：
--
作者：
Cardiel, Mario H.;Tumlin, James A.;Linnik, Matthew D.
通讯作者：
Linnik, Matthew D.
影响因子：
4.4
作者：
Agrawal, Hemant;Jacob, Noam;Jacob, Chaim O.
通讯作者：
Jacob, Chaim O.
DOI：
10.1084/jem.189.10.1639
发表时间：
1999-05-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chan OT;Hannum LG;Haberman AM;Madaio MP;Shlomchik MJ
通讯作者：
Shlomchik MJ
影响因子：
--
作者：
Baker, KP;Edwards, BM;Albert, VR
通讯作者：
Albert, VR