Spasmolytic polypeptide-expressing metaplasia (SPEM) cell lineages can be an origin of gastric cancer.
Spasmolytic polypeptide-expressing metaplasia (SPEM) cell lineages can be an origin of gastric cancer.
复制标题
表达解痉多肽的化生（SPEM）细胞谱系可能是胃癌的起源。
DOI：
10.1002/path.6089
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Goldenring,JamesR
中科院分区：
文献类型：
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作者：
Goldenring,JamesR
Intestinal‐type gastric cancer arises in a field of precancerous metaplastic lineages. Two types of metaplastic glands are found in the stomachs of humans with the characteristics of pyloric metaplasia or intestinal metaplasia. While spasmolytic polypeptide‐expressing metaplasia (SPEM) cell lineages have been identified in both pyloric metaplasia and incomplete intestinal metaplasia, it has been unclear whether SPEM lineages or intestinal lineages can give rise to dysplasia and cancer. A recent article published inThe Journal of Pathologydescribes a patient with evidence of an activatingKras(G12D) mutation in SPEM that is propagated into adenomatous and cancerous lesions which manifest further oncogenic mutations. This case therefore supports the concept that SPEM lineages can serve as a direct precursor for dysplasia and intestinal‐type gastric cancer. © 2023 The Pathological Society of Great Britain and Ireland.
