Tackling malaria transmission in sub-Saharan Africa.
Tackling malaria transmission in sub-Saharan Africa.
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DOI：
10.1016/s2214-109x(18)30197-9
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发表时间：
2018-06
期刊：
影响因子：
--
通讯作者：
Laufer M
中科院分区：
文献类型：
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作者：
Cohee L;Laufer M
在全球疟疾负担大幅减轻近20年后，进展停滞不前。1全球科学和政策领导人一致认为，要实现消灭疟疾，干预措施不仅必须侧重于预防疟疾疾病，而且还必须侧重于减少疟疾传播。2 5岁以下儿童和孕妇患严重疾病的风险最高，以前一直是疟疾控制干预措施的主要目标。然而，表面上健康的年龄较大的儿童和成人也藏有可传播的疟疾寄生虫，撒哈拉以南非洲各地的几项研究表明，学龄儿童的疟疾负担未得到充分重视，他们的感染率往往高于年幼儿童和成人。3-6虽然学龄儿童感染很少导致严重疾病或寻求治疗，但它们与贫血、缺课和受教育程度下降有关。7用有效的抗疟药物对在校儿童进行大规模治疗，大大降低了疟疾感染和贫血的发病率，并提高了认知能力。
After almost two decades of substantial reductions in the global burden of malaria, progress has stagnated. 1 Global scientific and policy leaders agree that to achieve malaria eradication, interventions must focus not only on preventing malaria disease but also on decreasing malaria transmission. 2 Children younger than 5 years and pregnant women are at the highest risk of severe disease and have previously been the primary targets of malaria control interventions. However, apparently healthy older children and adults also harbour transmissible malaria parasites.Several studies from across sub-Saharan Africa have revealed an underappreciated burden of malaria in school-age children, among whom prevalence of infection is often higher than that among younger children and adults. 3–6 Although infections in schoolage children rarely lead to severe disease or treatment seeking, they are associated with anaemia, school absences, and decreased educational attainment. 7 Mass treatment of school children with effective antimalarial drugs substantially lowers the prevalence of malaria infection and anaemia and improves cognitive