Systematic Investigation of the Relationship between High Myopia and Polymorphisms of the MMP2, TIMP2, and TIMP3 Genes by a DNA Pooling Approach
Systematic Investigation of the Relationship between High Myopia and Polymorphisms of the MMP2, TIMP2, and TIMP3 Genes by a DNA Pooling Approach
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DOI：
10.1167/iovs.11-7286
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发表时间：
2011-05-01
影响因子：
4.4
通讯作者：
Yip, Shea Ping
中科院分区：
文献类型：
--
作者：
Leung, Kim Hung;Yiu, Wai Chi;Yip, Shea Ping
目的。本研究探讨了高度近视与3个近视候选基因基质金属蛋白酶2 （MMP2）和金属蛋白酶2和-3组织抑制剂（TIMP2和TIMP3）参与巩膜重塑的关系。这项研究招募了一些没有血缘关系的成年汉族，他们都是高度近视（相当于球形），
PURPOSE. This study examined the relationship between high myopia and three myopia candidate genes-matrix metalloproteinase 2 (MMP2) and tissue inhibitor of metalloproteinase-2 and -3 (TIMP2 and TIMP3)-involved in scleral remodeling.METHODS. Recruited for the study were unrelated adult Han Chinese who were high myopes (spherical equivalent,