Cost-effective diffuse reflectance spectroscopy device for quantifying tissue absorption and scattering in vivo
Cost-effective diffuse reflectance spectroscopy device for quantifying tissue absorption and scattering in vivo
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DOI：
10.1117/1.3041500
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发表时间：
2008-11-01
影响因子：
3.5
通讯作者：
Ramanujam, Nirmala
中科院分区：
文献类型：
--
作者：
Yu, Bing;Lo, Justin Y.;Ramanujam, Nirmala
一种混合光学设备，使用多模光纤耦合到一个可调光源的照明和2.4毫米光电二极管与组织表面接触的检测，开发作为第一步，我们的目标是开发一个具有成本效益的，微型光谱成像设备，以映射组织的光学特性在体内。该装置加上一个逆蒙特卡罗模型的反射率被证明是准确地量化组织的吸收和散射的组织状混浊的合成幻影具有广泛的光学特性。量化吸收和散射系数的总体误差分别为6.0 +/- 5.6和6.1 +/-4.7%。与基于光纤的检测相比，将检测器置于组织表面可以显着提高光收集效率，从而降低对高灵敏度复杂检测器的需求，并且这种设计可以轻松扩展为定量光谱成像系统，用于绘制组织光学特性体内。(C)2008年，由光学仪器工程师协会（Society of Photo-Optical Instrumentation Engineers）主办。[DOI：10.1117/1.3041500]
A hybrid optical device that uses a multimode fiber coupled to a tunable light source for illumination and a 2.4-mm photodiode for detection in contact with the tissue surface is developed as a first step toward our goal of developing a cost-effective, miniature spectral imaging device to map tissue optical properties in vivo. This device coupled with an inverse Monte Carlo model of reflectance is demonstrated to accurately quantify tissue absorption and scattering in tissue-like turbid synthetic phantoms with a wide range of optical properties. The overall errors for quantifying the absorption and scattering coefficients are 6.0 +/- 5.6 and 6.1 +/- 4.7%, respectively. Compared with fiber-based detection, having the detector right at the tissue surface can significantly improve light collection efficiency, thus reducing the requirement for sophisticated detectors with high sensitivity, and this design can be easily expanded into a quantitative spectral imaging system for mapping tissue optical properties in vivo. (C) 2008 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3041500]